Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways

Inge E Krabbendam, Birgit Honrath, Carsten Culmsee, Amalia M Dolga

Research output: Contribution to journalReview articleAcademicpeer-review

33 Citations (Scopus)
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Abstract

Ca2+-activated K+ channels (KCa) are expressed at the plasma membrane and in cellular organelles. Expression of all KCa channel subtypes (BK, IK and SK) has been detected at the inner mitochondrial membrane of several cell types. Primary functions of these mitochondrial KCa channels include the regulation of mitochondrial ROS production, maintenance of the mitochondrial membrane potential and preservation of mitochondrial calcium homeostasis. These channels are therefore thought to contribute to cellular protection against oxidative stress through mitochondrial mechanisms of preconditioning. In this review, we summarize the current knowledge on mitochondrial KCa channels, and their role in mitochondrial function in relation to cell death and survival pathways. More specifically, we systematically discuss studies on the role of these mitochondrial KCa channels in pharmacological preconditioning, and according protective effects on ischemic insults to the brain and the heart.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalCell calcium
Volume69
DOIs
Publication statusPublished - Jan-2018

Keywords

  • Journal Article
  • Review
  • CALCIUM-IONS
  • NEURODEGENERATIVE DISEASES
  • PERMEABILITY TRANSITION PORE
  • ACTIVATED POTASSIUM CHANNELS
  • (ROS)-INDUCED ROS RELEASE
  • NECROSIS-FACTOR-ALPHA
  • PARKINSONS-DISEASE
  • BK CHANNEL
  • RAT-BRAIN
  • CARDIAC MYOCYTES

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