Mitochondrial epigenetics: an overlooked layer of regulation?

Monique G. P. van der Wijst, Marianne G. Rots*

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

54 Citations (Scopus)

Abstract

Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalTrends in Genetics
Volume31
Issue number7
DOIs
Publication statusPublished - Jul-2015

Keywords

  • mitochondrial epigenetics
  • mitoepigenetics
  • DNA methylation
  • DNA hydroxymethylation
  • mtDNMT1
  • mtDNA
  • DNA
  • METHYLATION
  • TRANSCRIPTION
  • DISEASE
  • SHOWS

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