Mitochondrial epigenetics: an overlooked layer of regulation?

Monique G. P. van der Wijst; Marianne G. Rots

doi:10.1016/j.tig.2015.03.009

Mitochondrial epigenetics: an overlooked layer of regulation?

Monique G. P. van der Wijst, Marianne G. Rots^*

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic › peer-review

70 Citations (Scopus)

Abstract

Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	Trends in Genetics
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.tig.2015.03.009
Publication status	Published - Jul-2015

Keywords

mitochondrial epigenetics
mitoepigenetics
DNA methylation
DNA hydroxymethylation
mtDNMT1
mtDNA
DNA
METHYLATION
TRANSCRIPTION
DISEASE
SHOWS

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title = "Mitochondrial epigenetics: an overlooked layer of regulation?",

abstract = "Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.",

keywords = "mitochondrial epigenetics, mitoepigenetics, DNA methylation, DNA hydroxymethylation, mtDNMT1, mtDNA, DNA, METHYLATION, TRANSCRIPTION, DISEASE, SHOWS",

author = "{van der Wijst}, {Monique G. P.} and Rots, {Marianne G.}",

year = "2015",

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AU - Rots, Marianne G.

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N2 - Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

AB - Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

KW - mitochondrial epigenetics

KW - mitoepigenetics

KW - DNA methylation

KW - DNA hydroxymethylation

KW - mtDNMT1

KW - mtDNA

KW - DNA

KW - METHYLATION

KW - TRANSCRIPTION

KW - DISEASE

KW - SHOWS

U2 - 10.1016/j.tig.2015.03.009

DO - 10.1016/j.tig.2015.03.009

M3 - Editorial

VL - 31

SP - 353

EP - 356

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

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ER -