MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer

MJW Berends; H Hollema; Y Wu; T van der Sluis; RGJ Mensink; KA ten Hoor; RH Sijmons; EGE de Vries; E Pras; MJE Mourits; RMW Hofstra; CHCM Buys; JH Kleibeuker; AGJ van der Zee

MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer

MJW Berends, H Hollema, Y Wu, T van der Sluis, RGJ Mensink, KA ten Hoor, RH Sijmons, EGE de Vries, E Pras, MJE Mourits, RMW Hofstra, CHCM Buys, JH Kleibeuker, AGJ van der Zee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The predictive value of MLH1 or MSH2 protein expression for the presence of truncating germline mutations was examined in benign and (pre)malignant endometrial samples from 3 patient groups: (1) 10 endometrial cancer patients from hereditary non-polyposis colorectal cancer (HNPCC) families with (n = 6) or without (n = 4) a known germline mutation; (11) 15 women from HNPCC families with (n = 7) or without (n = 8) a known germline mutation, who underwent endometrial sampling for non-malignant reasons; (III) 38 endometrial cancer patients 2001 Wiley-Liss. Inc.

Original language	English
Pages (from-to)	398-403
Number of pages	6
Journal	International Journal of Cancer
Volume	92
Issue number	3
Publication status	Published - 1-May-2001

Keywords

MLH1
MSH2
protein expression
endometrial cancer
endometrial hyperplasia
NONPOLYPOSIS COLORECTAL-CANCER
MISMATCH REPAIR GENES
HMLH1 PROMOTER HYPERMETHYLATION
MICROSATELLITE INSTABILITY
ALTERED EXPRESSION
CARCINOMA
TUMORS
MUTATIONS
HMSH2
FREQUENT

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Berends, MJW., Hollema, H., Wu, Y., van der Sluis, T., Mensink, RGJ., ten Hoor, KA., Sijmons, RH., de Vries, EGE., Pras, E., Mourits, MJE., Hofstra, RMW., Buys, CHCM., Kleibeuker, JH., & van der Zee, AGJ. (2001). MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer. International Journal of Cancer, 92(3), 398-403.

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title = "MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer",

abstract = "The predictive value of MLH1 or MSH2 protein expression for the presence of truncating germline mutations was examined in benign and (pre)malignant endometrial samples from 3 patient groups: (1) 10 endometrial cancer patients from hereditary non-polyposis colorectal cancer (HNPCC) families with (n = 6) or without (n = 4) a known germline mutation; (11) 15 women from HNPCC families with (n = 7) or without (n = 8) a known germline mutation, who underwent endometrial sampling for non-malignant reasons; (III) 38 endometrial cancer patients 2001 Wiley-Liss. Inc.",

keywords = "MLH1, MSH2, protein expression, endometrial cancer, endometrial hyperplasia, NONPOLYPOSIS COLORECTAL-CANCER, MISMATCH REPAIR GENES, HMLH1 PROMOTER HYPERMETHYLATION, MICROSATELLITE INSTABILITY, ALTERED EXPRESSION, CARCINOMA, TUMORS, MUTATIONS, HMSH2, FREQUENT",

author = "MJW Berends and H Hollema and Y Wu and {van der Sluis}, T and RGJ Mensink and {ten Hoor}, KA and RH Sijmons and {de Vries}, EGE and E Pras and MJE Mourits and RMW Hofstra and CHCM Buys and JH Kleibeuker and {van der Zee}, AGJ",

year = "2001",

month = may,

day = "1",

language = "English",

volume = "92",

pages = "398--403",

journal = "International Journal of Cancer",

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}

Berends, MJW, Hollema, H, Wu, Y, van der Sluis, T, Mensink, RGJ, ten Hoor, KA, Sijmons, RH, de Vries, EGE, Pras, E, Mourits, MJE, Hofstra, RMW, Buys, CHCM, Kleibeuker, JH & van der Zee, AGJ 2001, 'MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer', International Journal of Cancer, vol. 92, no. 3, pp. 398-403.

TY - JOUR

T1 - MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer

AU - Berends, MJW

AU - Hollema, H

AU - Wu, Y

AU - van der Sluis, T

AU - Mensink, RGJ

AU - ten Hoor, KA

AU - Sijmons, RH

AU - de Vries, EGE

AU - Pras, E

AU - Mourits, MJE

AU - Hofstra, RMW

AU - Buys, CHCM

AU - Kleibeuker, JH

AU - van der Zee, AGJ

PY - 2001/5/1

Y1 - 2001/5/1

N2 - The predictive value of MLH1 or MSH2 protein expression for the presence of truncating germline mutations was examined in benign and (pre)malignant endometrial samples from 3 patient groups: (1) 10 endometrial cancer patients from hereditary non-polyposis colorectal cancer (HNPCC) families with (n = 6) or without (n = 4) a known germline mutation; (11) 15 women from HNPCC families with (n = 7) or without (n = 8) a known germline mutation, who underwent endometrial sampling for non-malignant reasons; (III) 38 endometrial cancer patients 2001 Wiley-Liss. Inc.

AB - The predictive value of MLH1 or MSH2 protein expression for the presence of truncating germline mutations was examined in benign and (pre)malignant endometrial samples from 3 patient groups: (1) 10 endometrial cancer patients from hereditary non-polyposis colorectal cancer (HNPCC) families with (n = 6) or without (n = 4) a known germline mutation; (11) 15 women from HNPCC families with (n = 7) or without (n = 8) a known germline mutation, who underwent endometrial sampling for non-malignant reasons; (III) 38 endometrial cancer patients 2001 Wiley-Liss. Inc.

KW - MLH1

KW - MSH2

KW - protein expression

KW - endometrial cancer

KW - endometrial hyperplasia

KW - NONPOLYPOSIS COLORECTAL-CANCER

KW - MISMATCH REPAIR GENES

KW - HMLH1 PROMOTER HYPERMETHYLATION

KW - MICROSATELLITE INSTABILITY

KW - ALTERED EXPRESSION

KW - CARCINOMA

KW - TUMORS

KW - MUTATIONS

KW - HMSH2

KW - FREQUENT

M3 - Article

SN - 0020-7136

VL - 92

SP - 398

EP - 403

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 3

ER -

MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer

Abstract

Keywords

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