MMP9 potentiates pulmonary metastasis formation

Léon C L van Kempen, Lisa M Coussens

Research output: Contribution to journalReview articlepeer-review

139 Citations (Scopus)


Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

Original languageEnglish
Pages (from-to)251-252
Number of pages2
JournalCancer cell
Issue number4
Publication statusPublished - Oct-2002
Externally publishedYes


  • Animals
  • Disease Progression
  • Humans
  • Liver/blood supply
  • Lung Neoplasms/metabolism
  • Macrophages/enzymology
  • Matrix Metalloproteinase 9/physiology
  • Precancerous Conditions
  • Vascular Endothelial Growth Factor Receptor-1/metabolism

Cite this