MMP9 potentiates pulmonary metastasis formation

Léon C L van Kempen; Lisa M Coussens

doi:10.1016/s1535-6108(02)00157-5

MMP9 potentiates pulmonary metastasis formation

Léon C L van Kempen
, Lisa M Coussens

Research output: Contribution to journal › Review article › peer-review

154 Citations (Scopus)

Abstract

Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

Original language	English
Pages (from-to)	251-252
Number of pages	2
Journal	Cancer cell
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/s1535-6108(02)00157-5
Publication status	Published - Oct-2002
Externally published	Yes

Keywords

Animals
Disease Progression
Humans
Liver/blood supply
Lung Neoplasms/metabolism
Macrophages/enzymology
Matrix Metalloproteinase 9/physiology
Precancerous Conditions
Vascular Endothelial Growth Factor Receptor-1/metabolism

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MMP9 potentiates pulmonary metastasis formation
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title = "MMP9 potentiates pulmonary metastasis formation",

abstract = "Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).",

keywords = "Animals, Disease Progression, Humans, Liver/blood supply, Lung Neoplasms/metabolism, Macrophages/enzymology, Matrix Metalloproteinase 9/physiology, Precancerous Conditions, Vascular Endothelial Growth Factor Receptor-1/metabolism",

author = "\{van Kempen\}, \{L{\'e}on C L\} and Coussens, \{Lisa M\}",

year = "2002",

month = oct,

doi = "10.1016/s1535-6108(02)00157-5",

language = "English",

volume = "2",

pages = "251--252",

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T1 - MMP9 potentiates pulmonary metastasis formation

AU - van Kempen, Léon C L

AU - Coussens, Lisa M

PY - 2002/10

Y1 - 2002/10

N2 - Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

AB - Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

KW - Animals

KW - Disease Progression

KW - Humans

KW - Liver/blood supply

KW - Lung Neoplasms/metabolism

KW - Macrophages/enzymology

KW - Matrix Metalloproteinase 9/physiology

KW - Precancerous Conditions

KW - Vascular Endothelial Growth Factor Receptor-1/metabolism

U2 - 10.1016/s1535-6108(02)00157-5

DO - 10.1016/s1535-6108(02)00157-5

M3 - Review article

C2 - 12398887

SN - 1535-6108

VL - 2

SP - 251

EP - 252

JO - Cancer cell

JF - Cancer cell

IS - 4

ER -

MMP9 potentiates pulmonary metastasis formation

Abstract

Keywords

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