Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

Karin Monteiro Moreira; Tatiana Lima Ferreira; Debora Cristina Hipolide; Raquel Vecchio Fomari; Sergio Tufik; Maria Gabriela Menezes Oliveira

Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

Karin Monteiro Moreira
, Tatiana Lima Ferreira
, Debora Cristina Hipolide
, Raquel Vecchio Fomari
, Sergio Tufik
, Maria Gabriela Menezes Oliveira^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).

Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.

Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.

Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.

Original language	English
Pages (from-to)	990-993
Number of pages	4
Journal	Sleep
Volume	33
Issue number	7
Publication status	Published - 1-Jul-2010

Keywords

Cognitive enhancer
emotional memory
acquisition
retrieval
learning
sleep
WORKING-MEMORY
REACTION-TIME
MICE
PERFORMANCE
MODULATION
STRESS

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title = "Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats",

abstract = "Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.",

keywords = "Cognitive enhancer, emotional memory, acquisition, retrieval, learning, sleep, WORKING-MEMORY, REACTION-TIME, MICE, PERFORMANCE, MODULATION, STRESS",

author = "Moreira, \{Karin Monteiro\} and Ferreira, \{Tatiana Lima\} and Hipolide, \{Debora Cristina\} and Fomari, \{Raquel Vecchio\} and Sergio Tufik and \{Menezes Oliveira\}, \{Maria Gabriela\}",

year = "2010",

month = jul,

day = "1",

language = "English",

volume = "33",

pages = "990--993",

journal = "Sleep",

issn = "0161-8105",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

AU - Moreira, Karin Monteiro

AU - Ferreira, Tatiana Lima

AU - Hipolide, Debora Cristina

AU - Fomari, Raquel Vecchio

AU - Tufik, Sergio

AU - Menezes Oliveira, Maria Gabriela

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.

AB - Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.

KW - Cognitive enhancer

KW - emotional memory

KW - acquisition

KW - retrieval

KW - learning

KW - sleep

KW - WORKING-MEMORY

KW - REACTION-TIME

KW - MICE

KW - PERFORMANCE

KW - MODULATION

KW - STRESS

M3 - Article

SN - 0161-8105

VL - 33

SP - 990

EP - 993

JO - Sleep

JF - Sleep

IS - 7

ER -

Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

Abstract

Keywords

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