Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults

George M. Opie, Aylin K. Post, Michael C. Ridding, Ulf Ziemann, John G. Semmler*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Objective: To examine the effect of priming paired associative stimulation (PAS) on the modulation of motor cortex (M1) plasticity in young and old adults.

    Methods: Fifteen young (20-27 yrs) and 15 old (61-79 yrs) subjects participated in 3 experimental sessions, with each session involving two consecutive PAS protocols separated by 10 mins. The first (priming) protocol was either PAS(LTP) (ISI = N20 latency + 2 ms), PASLTD (ISI = N20 latency - 10 ms), or PAS(Control) (ISI = 100 ms), whereas the second (test) protocol was always PASLTP. Changes in M1 excitability were assessed from motor evoked potentials (MEPs) in a hand muscle.

    Results: In young subjects, MEPs were larger after PAS(LTP) + PAS(LTP) than PAS(LTD) + PAS(LTP) (P <0.0001) and PAS(Control) + PAS(LTP) (P = 0.0008), whereas the response to PAS(Control) + PAS(LTP) was not different to PAS(LTD) + PAS(LTP) (P = 0.3). In old subjects, MEPs were smaller after PAS(LTP) + PAS(LTP) compared with PAS(Control) + PAS(LTP) (P = 0.02), whereas PAS(LTD) + PAS(LTP) was similar to PAS(Control) + PAS(LTP) (P = 0.08). Age-related comparisons within each priming condition showed that the response to PAS(LTP) + PAS(LTP) was significantly greater in young subjects (P = 0.03).

    Conclusion: Data show that priming with PASLTP was effective in young but not old subjects.

    Significance: These findings suggest a limited utility of priming PAS for augmenting plasticity induction in old adults. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)763-769
    Number of pages7
    JournalClinical Neurophysiology
    Volume128
    Issue number5
    DOIs
    Publication statusPublished - May-2017

    Keywords

    • Ageing
    • Primary motor cortex
    • Transcranial magnetic stimulation
    • Paired-associative stimulation
    • Neuroplasticity
    • Metaplasticity
    • LONG-TERM POTENTIATION
    • INTERINDIVIDUAL VARIABILITY
    • DIFFERENTIAL MODULATION
    • DEPENDENT PLASTICITY
    • CORTEX EXCITABILITY
    • NERVE-CONDUCTION
    • AGE-DEPENDENCE
    • METAPLASTICITY
    • INDUCTION
    • PROTOCOLS

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