Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

Maria Clara Barbosa-de-Oliveira; Paolo Oliveira-Melo; Marcos Henrique Gonçalves da Silva; Felipe Andrade Carvalho da Silva; Felipe Andrade Carvalho da Silva; Bruno Vinicios Silva de Araujo; Moacir Franco de Oliveira; Aristides Tadeu Correia; Sidnei Miyoshi Sakamoto; Samuel Santos Valença; Manuella Lanzetti; Martina Schmidt; Emanuel Kennedy-Feitosa

doi:10.3390/antiox12061258

Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Gonçalves da Silva, Felipe Andrade Carvalho da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valença, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa

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Abstract

This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.

Original language	English
Article number	1258
Number of pages	14
Journal	Antioxidants (Basel, Switzerland)
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/antiox12061258
Publication status	Published - 11-Jun-2023

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Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in MiceFinal publisher's version, 2.09 MBLicence: CC BY

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Barbosa-de-Oliveira, M. C., Oliveira-Melo, P., Gonçalves da Silva, M. H., Andrade Carvalho da Silva, F., Andrade Carvalho da Silva, F., Silva de Araujo, B. V., Franco de Oliveira, M., Tadeu Correia, A., Miyoshi Sakamoto, S., Valença, S. S., Lanzetti, M., Schmidt, M., & Kennedy-Feitosa, E. (2023). Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. Antioxidants (Basel, Switzerland), 12(6), Article 1258. https://doi.org/10.3390/antiox12061258

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title = "Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice",

abstract = "This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.",

author = "Barbosa-de-Oliveira, {Maria Clara} and Paolo Oliveira-Melo and {Gon{\c c}alves da Silva}, {Marcos Henrique} and {Andrade Carvalho da Silva}, Felipe and {Andrade Carvalho da Silva}, Felipe and {Silva de Araujo}, {Bruno Vinicios} and {Franco de Oliveira}, Moacir and {Tadeu Correia}, Aristides and {Miyoshi Sakamoto}, Sidnei and Valen{\c c}a, {Samuel Santos} and Manuella Lanzetti and Martina Schmidt and Emanuel Kennedy-Feitosa",

year = "2023",

month = jun,

day = "11",

doi = "10.3390/antiox12061258",

language = "English",

volume = "12",

journal = "Antioxidants (Basel, Switzerland)",

issn = "2076-3921",

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number = "6",

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Barbosa-de-Oliveira, MC, Oliveira-Melo, P, Gonçalves da Silva, MH, Andrade Carvalho da Silva, F, Andrade Carvalho da Silva, F, Silva de Araujo, BV, Franco de Oliveira, M, Tadeu Correia, A, Miyoshi Sakamoto, S, Valença, SS, Lanzetti, M, Schmidt, M & Kennedy-Feitosa, E 2023, 'Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice', Antioxidants (Basel, Switzerland), vol. 12, no. 6, 1258. https://doi.org/10.3390/antiox12061258

Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. / Barbosa-de-Oliveira, Maria Clara; Oliveira-Melo, Paolo; Gonçalves da Silva, Marcos Henrique et al.
In: Antioxidants (Basel, Switzerland), Vol. 12, No. 6, 1258, 11.06.2023.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

AU - Barbosa-de-Oliveira, Maria Clara

AU - Oliveira-Melo, Paolo

AU - Gonçalves da Silva, Marcos Henrique

AU - Andrade Carvalho da Silva, Felipe

AU - Silva de Araujo, Bruno Vinicios

AU - Franco de Oliveira, Moacir

AU - Tadeu Correia, Aristides

AU - Miyoshi Sakamoto, Sidnei

AU - Valença, Samuel Santos

AU - Lanzetti, Manuella

AU - Schmidt, Martina

AU - Kennedy-Feitosa, Emanuel

PY - 2023/6/11

Y1 - 2023/6/11

N2 - This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.

AB - This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.

U2 - 10.3390/antiox12061258

DO - 10.3390/antiox12061258

M3 - Article

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SN - 2076-3921

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JO - Antioxidants (Basel, Switzerland)

JF - Antioxidants (Basel, Switzerland)

IS - 6

M1 - 1258

ER -

Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

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