Modulation of Immune Responses by Particle Size and Shape

Maksim V Baranov*, Manoj Kumar, Stefano Sacanna, Shashi Thutupalli, Geert van den Bogaart*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

33 Citations (Scopus)
63 Downloads (Pure)

Abstract

The immune system has to cope with a wide range of irregularly shaped pathogens that can actively move (e.g., by flagella) and also dynamically remodel their shape (e.g., transition from yeast-shaped to hyphal fungi). The goal of this review is to draw general conclusions of how the size and geometry of a pathogen affect its uptake and processing by phagocytes of the immune system. We compared both theoretical and experimental studies with different cells, model particles, and pathogenic microbes (particularly fungi) showing that particle size, shape, rigidity, and surface roughness are important parameters for cellular uptake and subsequent immune responses, particularly inflammasome activation and T cell activation. Understanding how the physical properties of particles affect immune responses can aid the design of better vaccines.

Original languageEnglish
Article number607945
Number of pages23
JournalFrontiers in Immunology
Volume11
DOIs
Publication statusPublished - Feb-2021

Keywords

  • phagocytosis
  • F-actin (filamentous actin)
  • pathogens
  • vaccination
  • endocytosis

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