Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation

Gertrude J Nieuwenhuijs-Moeke*, Dirk J Bosch, Henri G D Leuvenink

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion phase; therefore, the intra-operative period seems an attractive window of opportunity to modulate IRI and improve short- and potentially long-term graft outcome. Commonly used volatile anesthetics such as sevoflurane and isoflurane have been shown to interfere with many of the pathophysiological processes involved in the injurious cascade of IRI. Therefore, volatile anesthetic (VA) agents might be the preferred anesthetics used during the transplantation procedure. This review highlights the molecular and cellular protective points of engagement of VA shown in in vitro studies and in vivo animal experiments, and the potential translation of these results to the clinical setting of kidney transplantation.

Original languageEnglish
Article number2727
Number of pages23
JournalInternational Journal of Molecular Sciences
Volume22
Issue number5
DOIs
Publication statusPublished - 1-Apr-2021

Keywords

  • Anesthetics, Inhalation/therapeutic use
  • Animals
  • Humans
  • Isoflurane/therapeutic use
  • Kidney/metabolism
  • Kidney Transplantation
  • Reperfusion Injury/prevention & control
  • Sevoflurane/therapeutic use

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