Molecular cytogenetics of lymphoma: where do we stand in 2010?

Philip Kluin*, Ed Schuuring

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

23 Citations (Scopus)

Abstract

For the past 20 years most malignant lymphomas have been classified as clinicopathological entities, each with its own combination of clinical, morphological, immunophenotypic and molecular genetic characteristics. Molecular and cytogenetic abnormalities can be detected by a wide range of techniques, ranging from conventional karyotyping to single nucleotide polymorphism analysis. In this review, we consider the common genetic abnormalities found in lymphoma and discuss the advantages and disadvantages of individual techniques used in their detection. Finally, we discuss briefly possible novel developments in the field of lymphoma diagnostics.

Original languageEnglish
Pages (from-to)128-144
Number of pages17
JournalHistopathology
Volume58
Issue number1
DOIs
Publication statusPublished - Jan-2011

Keywords

  • cytogenetics
  • lymphoma
  • review
  • IN-SITU HYBRIDIZATION
  • MANTLE CELL LYMPHOMA
  • COMPARATIVE GENOMIC HYBRIDIZATION
  • POLYMERASE-CHAIN-REACTION
  • PARAFFIN-EMBEDDED TISSUE
  • CONCERTED ACTION BMH4-CT98-3936
  • CENTRAL-NERVOUS-SYSTEM
  • GENE-EXPRESSION
  • MALIGNANT-LYMPHOMA
  • CYCLIN D1

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