Molecular definitions of autophagy and related processes

Lorenzo Galluzzi*, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Francesco Cecconi, Augustine MK Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Jayanta Debnath, Vojo Deretic, Ivan Dikic, Eeva-Liisa Eskelinen, Gian Maria Fimia, Simone Fulda, David A. Gewirtz, Douglas R. Green, Malene HansenJ. Wade Harper, Marja Jäättelä, Terje Johansen, Gabor Juhasz, Alec C. Kimmelman, Claudine Kraft, Nicholas T. Ktistakis, Sharad Kumar, Beth Levine, Carlos Lopez-Otin, Frank Madeo, Sascha Martens, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Münz, Leon O. Murphy, Josef Martin Penninger, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Laura Santambrogio, Luca Scorrano, Anna Katharina Simon, Hans-Uwe Simon, Anne Simonsen, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Guido Kroemer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1170 Citations (Scopus)

Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Original languageEnglish
Pages (from-to)1811-1836
Number of pages26
JournalThe EMBO Journal
Volume36
Issue number13
Early online date8-Jun-2017
DOIs
Publication statusPublished - 3-Jul-2017

Keywords

  • chaperone-mediated autophagy
  • LC3-associated phagocytosis
  • microautophagy
  • mitophagy
  • xenophagy
  • CHAPERONE-MEDIATED AUTOPHAGY
  • PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES
  • YEAST SACCHAROMYCES-CEREVISIAE
  • ENDOPLASMIC-RETICULUM TURNOVER
  • INNATE IMMUNE-RESPONSE
  • CENTRAL-NERVOUS-SYSTEM
  • PROGRAMMED CELL-DEATH
  • SELECTIVE AUTOPHAGY
  • C. ELEGANS
  • ANTIBACTERIAL AUTOPHAGY

Cite this