Molecular heterogeneity and angiogenesis in glioblastoma

    Research output: ThesisThesis fully internal (DIV)

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    Abstract

    The aim of this thesis was the assessment of the differential molecular characteristics and functional responses of glioblastomas with dissimilar phenotypes. The characteristics of transcriptional subclasses were studied in detail through the definition of molecular subclasses at protein level and the assessment of kinase activity profiles and vascularization patterns. In addition, the plasticity or interchangeability of these molecular phenotypes was studied, and the second part of the thesis then focused on the role of angiogenesis in glioblastoma in general. The thesis is concluded with the exploration of the druggability of the vascular compartment in glioblastoma.
    Translated title of the contributionMoleculaire Heterogeniteit en Angiogenese in Glioblastoma
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Timens, Wim, Supervisor
    • Kruyt, Frank, Supervisor
    • den Dunnen, Wilfred, Co-supervisor
    • Bhat, K. P., Co-supervisor, External person
    • Kros, J. M., Assessment committee, External person
    • Wesseling, P., Assessment committee, External person
    • Groen, Rob, Assessment committee
    Award date27-Nov-2017
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-6233-790-9
    Electronic ISBNs978-94-6233-791-6
    Publication statusPublished - 2017

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