Molecular imaging of estrogen receptors

Michel van Kruchten

    Research output: ThesisThesis fully internal (DIV)

    2012 Downloads (Pure)

    Abstract

    For patients with estrogen receptor (ER) positive breast cancer, endocrine therapy plays a major role in both the adjuvant and palliative setting. For adequate treatment decision-making it is crucial to obtain up-to-date information on the ER-status of the tumor(s), since ER-expression is the sole predictor for response to endocrine therapy. Moreover, ER-status can change during the course of disease in up to 30% of the patients, and therefore treatments based on the ER-status of the primary tumor may be inadequate. Positron emission tomography (PET) imaging of ER-expression by use of the tracer 16α-[18F]fluoro-17β-oestradiol (FES) can give functional information about the ER-status of all lesions within the body. The aim of this thesis is to address the clinical potential of the FES-PET technique in breast and ovarian cancer patients.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Hospers, Geke, Supervisor
    • de Vries, Liesbeth, Supervisor
    • Glaudemans, Andor, Co-supervisor
    • de Vries, Erik, Co-supervisor
    • Boven, E., Assessment committee, External person
    • Nijman, Hans, Assessment committee
    • van der Wall, Elsken, Assessment committee, External person
    Award date17-Jun-2015
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-90-367-7944-9
    Electronic ISBNs978-90-367-7943-2
    Publication statusPublished - 2015

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