Molecular imaging of hypoxia with radiolabelled agents

Gilles Mees, Rudi Dierckx, Christel Vangestel, Christophe Van de Wiele*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    152 Citations (Scopus)

    Abstract

    Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant progression. This has led to the development of assays for the detection of hypoxia in patients in order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments. A variety of invasive and non-invasive approaches have been developed to measure tumour oxygenation including oxygen-sensitive electrodes and hypoxia marker techniques using various labels that can be detected by different methods such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), autoradiography and immunohistochemistry. This review aims to give a detailed overview of non-invasive molecular imaging modalities with radiolabelled PET and SPECT tracers that are available to measure tumour hypoxia.

    Original languageEnglish
    Pages (from-to)1674-1686
    Number of pages13
    JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
    Volume36
    Issue number10
    DOIs
    Publication statusPublished - Oct-2009

    Keywords

    • Hypoxia
    • PET
    • SPECT
    • Nitroimidazole
    • POSITRON-EMISSION-TOMOGRAPHY
    • CELL LUNG-CANCER
    • PREDICT RADIOTHERAPY RESPONSE
    • EXPERIMENTAL MOUSE-TUMORS
    • GLUCOSE METABOLIC-RATE
    • IN-VIVO EVALUATION
    • NECK-CANCER
    • F-18 FLUOROMISONIDAZOLE
    • RADIATION-THERAPY
    • IODOAZOMYCIN ARABINOSIDE

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