Molecular mechanisms of drug-induced thrombocytopenia

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Abstract

A wide range of drugs can induce thrombocytopenia. Molecular mechanisms for the formation of specific epitopes for all the drug-dependent antibodies appear to be very similar. A restricted set of glycoproteins on the platelet surface interacts with the drugs to form neoepitopes, to which the drug-dependent antibodies bind. Molecular mapping of antigenic sites may help characterize genetic polymorphisms that predispose to the formation of the antibody binding sites. Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalCurrent opinion in hematology
Volume8
Issue number5
Publication statusPublished - Sep-2001

Keywords

  • Antibodies
  • Antigens, CD31
  • Epitopes
  • Heparin
  • Humans
  • Models, Biological
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Glycoprotein GPIb-IX Complex
  • Thrombocytopenia

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