Molecular mechanisms of drug-induced thrombocytopenia

J K Burgess

Molecular mechanisms of drug-induced thrombocytopenia

J K Burgess

Groningen Research Institute for Asthma and COPD (GRIAC)

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

A wide range of drugs can induce thrombocytopenia. Molecular mechanisms for the formation of specific epitopes for all the drug-dependent antibodies appear to be very similar. A restricted set of glycoproteins on the platelet surface interacts with the drugs to form neoepitopes, to which the drug-dependent antibodies bind. Molecular mapping of antigenic sites may help characterize genetic polymorphisms that predispose to the formation of the antibody binding sites. Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia.

Original language	English
Pages (from-to)	294-298
Number of pages	5
Journal	Current opinion in hematology
Volume	8
Issue number	5
Publication status	Published - Sept-2001

Keywords

Antibodies
Antigens, CD31
Epitopes
Heparin
Humans
Models, Biological
Platelet Glycoprotein GPIIb-IIIa Complex
Platelet Glycoprotein GPIb-IX Complex
Thrombocytopenia

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Burgess, J. K. (2001). Molecular mechanisms of drug-induced thrombocytopenia. Current opinion in hematology, 8(5), 294-298. http://ovidsp.tx.ovid.com/sp-3.22.1b/ovidweb.cgi?QS2=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abstract = "A wide range of drugs can induce thrombocytopenia. Molecular mechanisms for the formation of specific epitopes for all the drug-dependent antibodies appear to be very similar. A restricted set of glycoproteins on the platelet surface interacts with the drugs to form neoepitopes, to which the drug-dependent antibodies bind. Molecular mapping of antigenic sites may help characterize genetic polymorphisms that predispose to the formation of the antibody binding sites. Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia.",

keywords = "Antibodies, Antigens, CD31, Epitopes, Heparin, Humans, Models, Biological, Platelet Glycoprotein GPIIb-IIIa Complex, Platelet Glycoprotein GPIb-IX Complex, Thrombocytopenia",

author = "Burgess, \{J K\}",

year = "2001",

month = sep,

language = "English",

volume = "8",

pages = "294--298",

journal = "Current opinion in hematology",

issn = "1065-6251",

publisher = "Lippincott Williams and Wilkins",

number = "5",

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Burgess, JK 2001, 'Molecular mechanisms of drug-induced thrombocytopenia', Current opinion in hematology, vol. 8, no. 5, pp. 294-298. <http://ovidsp.tx.ovid.com/sp-3.22.1b/ovidweb.cgi?QS2=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>

TY - JOUR

T1 - Molecular mechanisms of drug-induced thrombocytopenia

AU - Burgess, J K

PY - 2001/9

Y1 - 2001/9

N2 - A wide range of drugs can induce thrombocytopenia. Molecular mechanisms for the formation of specific epitopes for all the drug-dependent antibodies appear to be very similar. A restricted set of glycoproteins on the platelet surface interacts with the drugs to form neoepitopes, to which the drug-dependent antibodies bind. Molecular mapping of antigenic sites may help characterize genetic polymorphisms that predispose to the formation of the antibody binding sites. Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia.

AB - A wide range of drugs can induce thrombocytopenia. Molecular mechanisms for the formation of specific epitopes for all the drug-dependent antibodies appear to be very similar. A restricted set of glycoproteins on the platelet surface interacts with the drugs to form neoepitopes, to which the drug-dependent antibodies bind. Molecular mapping of antigenic sites may help characterize genetic polymorphisms that predispose to the formation of the antibody binding sites. Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia.

KW - Antibodies

KW - Antigens, CD31

KW - Epitopes

KW - Heparin

KW - Humans

KW - Models, Biological

KW - Platelet Glycoprotein GPIIb-IIIa Complex

KW - Platelet Glycoprotein GPIb-IX Complex

KW - Thrombocytopenia

M3 - Review article

C2 - 11604564

SN - 1065-6251

VL - 8

SP - 294

EP - 298

JO - Current opinion in hematology

JF - Current opinion in hematology

IS - 5

ER -

Molecular mechanisms of drug-induced thrombocytopenia

Abstract

Keywords

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