Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Casper Kierulf-Lassen; Gertrude J. Nieuwenhuijs-Moeke; Nicoline V. Krogstrup; Mihai Oltean; Bente Jespersen; Frank J. M. F. Dor

doi:10.1159/000437352

Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Casper Kierulf-Lassen^*, Gertrude J. Nieuwenhuijs-Moeke, Nicoline V. Krogstrup, Mihai Oltean, Bente Jespersen, Frank J. M. F. Dor

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized. (C) 2015 S. Karger AG, Basel

Original language	English
Pages (from-to)	151-183
Number of pages	33
Journal	European surgical research
Volume	55
Issue number	3
DOIs	https://doi.org/10.1159/000437352
Publication status	Published - 2015

Keywords

Acute kidney injury
Delayed graft function
Ischemia-reperfusion injury
Ischemic conditioning
Molecular mechanism
ACUTE KIDNEY INJURY
RANDOMIZED CONTROLLED-TRIAL
BYPASS GRAFT-SURGERY
PERCUTANEOUS CORONARY INTERVENTION
REPERFUSED RAT KIDNEYS
MAJOR LIVER RESECTION
MITOCHONDRIAL PERMEABILITY TRANSITION
ENDOTHELIAL PROGENITOR CELLS
ENDOPLASMIC-RETICULUM STRESS
100 CONSECUTIVE PATIENTS

Access to Document

10.1159/000437352

Handle.net

Persistent link

Supplementary Material for: Molecular Mechanisms of Renal Ischemic Conditioning Strategies
Kierulf-Lassen, C. (Contributor), Nieuwenhuijs-Moeke, G. (Contributor), Krogstrup, N. V. (Contributor), Oltean, M. (Contributor), Jespersen, B. (Contributor) & Dor, F. J. M. F. (Contributor), University of Groningen, 2-Sept-2015
DOI: 10.6084/m9.figshare.5128465.v1
Dataset

Cite this

@article{11022197ba8e443bbaaac6e6d09738aa,

title = "Molecular Mechanisms of Renal Ischemic Conditioning Strategies",

abstract = "Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized. (C) 2015 S. Karger AG, Basel",

keywords = "Acute kidney injury, Delayed graft function, Ischemia-reperfusion injury, Ischemic conditioning, Molecular mechanism, ACUTE KIDNEY INJURY, RANDOMIZED CONTROLLED-TRIAL, BYPASS GRAFT-SURGERY, PERCUTANEOUS CORONARY INTERVENTION, REPERFUSED RAT KIDNEYS, MAJOR LIVER RESECTION, MITOCHONDRIAL PERMEABILITY TRANSITION, ENDOTHELIAL PROGENITOR CELLS, ENDOPLASMIC-RETICULUM STRESS, 100 CONSECUTIVE PATIENTS",

author = "Casper Kierulf-Lassen and Nieuwenhuijs-Moeke, {Gertrude J.} and Krogstrup, {Nicoline V.} and Mihai Oltean and Bente Jespersen and Dor, {Frank J. M. F.}",

year = "2015",

doi = "10.1159/000437352",

language = "English",

volume = "55",

pages = "151--183",

journal = "European surgical research",

issn = "0014-312X",

publisher = "KARGER",

number = "3",

}

TY - JOUR

T1 - Molecular Mechanisms of Renal Ischemic Conditioning Strategies

AU - Kierulf-Lassen, Casper

AU - Nieuwenhuijs-Moeke, Gertrude J.

AU - Krogstrup, Nicoline V.

AU - Oltean, Mihai

AU - Jespersen, Bente

AU - Dor, Frank J. M. F.

PY - 2015

Y1 - 2015

N2 - Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized. (C) 2015 S. Karger AG, Basel

AB - Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized. (C) 2015 S. Karger AG, Basel

KW - Acute kidney injury

KW - Delayed graft function

KW - Ischemia-reperfusion injury

KW - Ischemic conditioning

KW - Molecular mechanism

KW - ACUTE KIDNEY INJURY

KW - RANDOMIZED CONTROLLED-TRIAL

KW - BYPASS GRAFT-SURGERY

KW - PERCUTANEOUS CORONARY INTERVENTION

KW - REPERFUSED RAT KIDNEYS

KW - MAJOR LIVER RESECTION

KW - MITOCHONDRIAL PERMEABILITY TRANSITION

KW - ENDOTHELIAL PROGENITOR CELLS

KW - ENDOPLASMIC-RETICULUM STRESS

KW - 100 CONSECUTIVE PATIENTS

U2 - 10.1159/000437352

DO - 10.1159/000437352

M3 - Review article

SN - 0014-312X

VL - 55

SP - 151

EP - 183

JO - European surgical research

JF - European surgical research

IS - 3

ER -

Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Abstract

Keywords

Access to Document

Handle.net

Datasets

Supplementary Material for: Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Cite this