Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Casper Kierulf-Lassen*, Gertrude J. Nieuwenhuijs-Moeke, Nicoline V. Krogstrup, Mihai Oltean, Bente Jespersen, Frank J. M. F. Dor

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

    21 Citations (Scopus)

    Abstract

    Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized. (C) 2015 S. Karger AG, Basel

    Original languageEnglish
    Pages (from-to)151-183
    Number of pages33
    JournalEuropean surgical research
    Volume55
    Issue number3
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Acute kidney injury
    • Delayed graft function
    • Ischemia-reperfusion injury
    • Ischemic conditioning
    • Molecular mechanism
    • ACUTE KIDNEY INJURY
    • RANDOMIZED CONTROLLED-TRIAL
    • BYPASS GRAFT-SURGERY
    • PERCUTANEOUS CORONARY INTERVENTION
    • REPERFUSED RAT KIDNEYS
    • MAJOR LIVER RESECTION
    • MITOCHONDRIAL PERMEABILITY TRANSITION
    • ENDOTHELIAL PROGENITOR CELLS
    • ENDOPLASMIC-RETICULUM STRESS
    • 100 CONSECUTIVE PATIENTS

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