Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof

Walter F Mangel; Paul Blainey; Vito Graziano; Andreas  Herrmann; William J McGrath; Antonius Martinus  van Oijen; Xiaoliang Sunney Xie

Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof

Walter F Mangel (Inventor), Paul Blainey (Inventor), Vito Graziano (Inventor), Andreas Herrmann (Inventor), William J McGrath (Inventor), Antonius Martinus van Oijen (Inventor), Xiaoliang Sunney Xie (Inventor)

Research output: Patent

Abstract

The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Original language	English
Patent number	WO2014012090
IPC	C12N 15/ 11 A I
Priority date	13/07/2012
Publication status	Published - 16-Jan-2014

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Mangel, W. F., Blainey, P., Graziano, V., Herrmann, A., McGrath, W. J., van Oijen, A. M., & Xie, X. S. (2014). Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof. (Patent No. WO2014012090). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2014012090A1&KC=A1&FT=D&ND=3&date=20140116&DB=&locale=en_EP

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title = "Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof",

abstract = "The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.",

author = "Mangel, {Walter F} and Paul Blainey and Vito Graziano and Andreas Herrmann and McGrath, {William J} and {van Oijen}, {Antonius Martinus} and Xie, {Xiaoliang Sunney}",

year = "2014",

month = jan,

day = "16",

language = "English",

type = "Patent",

note = "WO2014012090; C12N 15/ 11 A I",

}

Mangel, WF, Blainey, P, Graziano, V, Herrmann, A, McGrath, WJ, van Oijen, AM & Xie, XS Jan. 16 2014, Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof, Patent No. WO2014012090. <https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2014012090A1&KC=A1&FT=D&ND=3&date=20140116&DB=&locale=en_EP>

TY - PAT

T1 - Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof

AU - Mangel, Walter F

AU - Blainey, Paul

AU - Graziano, Vito

AU - Herrmann, Andreas

AU - McGrath, William J

AU - van Oijen, Antonius Martinus

AU - Xie, Xiaoliang Sunney

PY - 2014/1/16

Y1 - 2014/1/16

N2 - The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

AB - The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

M3 - Patent

M1 - WO2014012090

ER -

Molecular sleds comprising a positively -charged amino acid sequence and a molecular cargo and uses thereof

Abstract

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