Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study

Diego Peña; Adriaan J. Minnaard; André H.M. de Vries; Johannes G. de Vries; Bernard Feringa

doi:10.1021/o1027457t

Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study

Diego Peña
, Adriaan J. Minnaard
, André H.M. de Vries
, Johannes G. de Vries
, Bernard Feringa

Research output: Contribution to journal › Article › Academic › peer-review

92 Citations (Scopus)

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Abstract

Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.

Original language	English
Pages (from-to)	475-478
Number of pages	4
Journal	Organic letters
Volume	5
Issue number	4
DOIs	https://doi.org/10.1021/o1027457t
Publication status	Published - 20-Feb-2003

Keywords

HIGHLY ENANTIOSELECTIVE HYDROGENATION
ACID
COD

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title = "Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study",

abstract = "Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.",

keywords = "HIGHLY ENANTIOSELECTIVE HYDROGENATION, ACID, COD",

author = "Diego Pe{\~n}a and Minnaard, \{Adriaan J.\} and Vries, \{Andr{\'e} H.M. de\} and Vries, \{Johannes G. de\} and Bernard Feringa",

note = "Relation: http://www.rug.nl/scheikunde/ date\_submitted:2005 Rights: University of Groningen. Stratingh Institute",

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AU - Peña, Diego

AU - Minnaard, Adriaan J.

AU - Vries, André H.M. de

AU - Vries, Johannes G. de

AU - Feringa, Bernard

N1 - Relation: http://www.rug.nl/scheikunde/ date_submitted:2005 Rights: University of Groningen. Stratingh Institute

PY - 2003/2/20

Y1 - 2003/2/20

N2 - Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.

AB - Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.

KW - HIGHLY ENANTIOSELECTIVE HYDROGENATION

KW - ACID

KW - COD

U2 - 10.1021/o1027457t

DO - 10.1021/o1027457t

M3 - Article

SN - 1523-7060

VL - 5

SP - 475

EP - 478

JO - Organic letters

JF - Organic letters

IS - 4

ER -

Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study

Abstract

Keywords

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