Moonlighting proteins: An intriguing mode of multitasking

Daphne Huberts, I.J. van der Klei

Research output: Contribution to journalArticleAcademicpeer-review

274 Citations (Scopus)
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Abstract

Proteins are macromolecules, which perform a large variety of functions. Most of them have only a single function, but an increasing number of proteins are being identified as multifunctional. Moonlighting proteins form a special class of multifunctional proteins. They perform multiple autonomous and often unrelated functions without partitioning these functions into different domains of the protein. Striking examples are enzymes, which in addition to their catalytic function are involved in fully unrelated processes such as autophagy, protein transport or DNA maintenance. In this contribution we present an overview of our current knowledge of moonlighting proteins and discuss the significant implications for biomedical and fundamental research. (C) 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalBiochimica et Biophysica Acta-Molecular Cell Research
Volume1803
Issue number4
DOIs
Publication statusPublished - Apr-2010

Keywords

  • Multifunctional protein
  • Enzyme
  • Moonlighting
  • Gene sharing
  • ESCHERICHIA-COLI THIOREDOXIN
  • T7 DEOXYRIBONUCLEIC-ACID
  • ELEMENT-BINDING-PROTEIN
  • DNA-POLYMERASE-ACTIVITY
  • VACUOLAR H+-ATPASE
  • SACCHAROMYCES-CEREVISIAE
  • ALCOHOL OXIDASE
  • MYCOBACTERIUM-TUBERCULOSIS
  • PYRUVATE-CARBOXYLASE
  • CYTOCHROME-C

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