Morning and evening light treatment of seasonal affective disorder: response, relapse and prediction

Y. Meesters, J.H.C. Jansen, P.A. Lambers, A.L. Bouhuys, D.G.M. Beersma, R.H. van den Hoofdakker

    Research output: Contribution to journalArticleAcademicpeer-review

    42 Citations (Scopus)

    Abstract

    Patients with seasonal affective disorder were randomly assigned to treatment with light in the morning (9.00-12.00 a.m.; n = 16; ML) or evening (6.00-9.00 p.m.; n = 11; EL). An intensive 24-day assessment procedure revealed the same response rates: 57% for ML, 50% for EL. During the rest of the winter season a relatively low relapse rate of 54% was found. No differences between ML and EL were found in the time course of depressed mood or fatigue. A significant negative correlation was found between diurnal variation during baseline and therapeutic response: the larger the diurnal variation the less the response, indicating a potential negative predictive value for this symptom. There were no significant correlations between baseline fatigue or hypersomnia and response.

    Original languageEnglish
    Pages (from-to)165-177
    Number of pages13
    JournalJournal of Affective Disorders
    Volume28
    Issue number3
    DOIs
    Publication statusPublished - Jul-1993

    Keywords

    • SEASONAL AFFECTIVE DISORDER
    • MORNING VS EVENING LIGHT TREATMENT
    • RELAPSE
    • PREDICTION
    • DIURNAL VARIATION
    • FATIGUE
    • MAJOR DEPRESSIVE DISORDER
    • WINTER DEPRESSION
    • SLEEP-DEPRIVATION
    • DIURNAL-VARIATION
    • BRIGHT LIGHT
    • PHOTOTHERAPY
    • THERAPY
    • ANTIDEPRESSANT
    • SYMPTOMS
    • MOOD

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