Morphological aspects of recurrent prostate cancer: on molecular imaging for local salvage treatment

Maxim Rybalov

    Research output: ThesisThesis fully internal (DIV)

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    Detection and staging of recurrent prostate cancer after surgery or radiation treatment is still one of the important clinical problems. At present there is no conventional imaging technique that can determine the exact localization of recurrent tumors, mostly for their small size. With a growing interest and possibilities of focal treatment of recurrent prostate cancer by ablative treatments like high intensity focused ultrasound and cryoablation, patient selection could be improved if the site of recurrence and its extent could be visualized. The aim of this thesis was to study the clinical value of 11C-choline PET/CT in recurrent prostate cancer and explore its potential for image guided cryoablation in future. The results of the clinical studies showed that 11C-choline PET/CT has a high overall sensitivity in detection of a local recurrence in the prostate after external beam radiotherapy (EBRT) on a patient based analysis. So it could be useful for the selection of patients with a biochemical recurrence after radiotherapy for whole organ salvage cryoablation of the prostate. At the same time the results of the clinical studies showed that 11C-choline PET/CT has a low accuracy in the characterization of a local recurrence in the prostate after EBRT on a lesion based analysis. This limits the use of 11C-choline PET/CT as routine imaging technique for image guided focal treatment, probably by the non-cancer specific nature of the choline tracer. We identified cancer specific targets in recurrent prostate cancer, which could improve the clinical value of PET/CT or PET/MRI in near future.
    Translated title of the contributionMorfologische aspecten in terugkerende prostaatkanker
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • de Jong, Igle Jan, Supervisor
    • Dierckx, Rudi, Supervisor
    • Al-Shukri, Salman, Supervisor, External person
    Award date4-Mar-2015
    Place of Publication[S.l.]
    Print ISBNs978-90-367-7669-1
    Electronic ISBNs978-90-367-7668-4
    Publication statusPublished - 2015

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