Mortality in patients with Dupuytren’s disease in the first 5 years after diagnosis: a population-based survival analysis

Bente A van den Berge, Feikje Groenhof, Paul M N Werker, Dominic Furniss, Rachel Kuo, Edwin R van den Heuvel, Dieuwke C Broekstra*

*Corresponding author for this work

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Abstract

Previous studies suggest that Dupuytren’s disease is associated with increased mortality, but most studies failed to account for important confounders. In this population-based cohort study, general practitioners’ (GP) data were linked to Statistics Netherlands to register all-cause and disease-specific mortality. Patients with Dupuytren’s disease were identified using the corresponding diagnosis code and assessing free-text fields from GP consultations. Multiple imputations were performed to estimate missing values of covariates, followed by 1:7 propensity score matching to balance cases with controls on confounding factors. A frailty proportional hazard model was used to compare mortality between both groups. Out of 209,966 individuals, 2561 patients with Dupuytren’s disease were identified and matched to at least four controls. After a median follow-up of 5 years, mortality was found to be actually reduced in patients with Dupuytren’s disease. There was no difference in mortality secondary to cancer or cardiovascular disease. Future studies with longer average follow-up using longitudinal data should clarify these associations in the longer term. Level of evidence: III.

Original languageEnglish
JournalJournal of Hand Surgery (European Volume)
DOIs
Publication statusE-pub ahead of print - 15-Mar-2024

Keywords

  • Dupuytren’s disease
  • epidemiology
  • mortality
  • propensity score
  • survival

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