MRI for diagnosis of post-renal transplant complications: current state-of-the-art and future perspectives

Rianne Schutter*, Veerle A. Lantinga, Ronald J. H. Borra, Cyril Moers

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Kidney transplantation has developed into a widespread procedure to treat end stage renal failure, with transplantation results improving over the years. Postoperative complications have decreased over the past decades, but are still an important cause of morbidity and mortality. Early accurate diagnosis and treatment is the key to prevent renal allograft impairment or even graft loss. Ideally, a diagnostic tool should be able to detect post-transplant renal dysfunction, differentiate between the different causes and monitor renal function during and after therapeutic interventions. Non-invasive imaging modalities for diagnostic purposes show promising results. Magnetic resonance imaging (MRI) techniques have a number of advantages, such as the lack of ionizing radiation and the possibility to obtain relevant tissue information without contrast, reducing the risk of contrast-induced nephrotoxicity. However, most techniques still lack the specificity to distinguish different types of parenchymal diseases. Despite some promising outcomes, MRI is still barely used in the post-transplantation diagnostic process. The aim of this review is to survey the current literature on the relevance and clinical applicability of diagnostic MRI modalities for the detection of various types of complications after kidney transplantation.

Original languageEnglish
Number of pages13
JournalMagnetic resonance materials in physics biology and medicine
DOIs
Publication statusPublished - 26-Dec-2019

Keywords

  • Magnetic resonance imaging
  • Kidney transplantation
  • Complications
  • Renal allograft
  • MAGNETIC-RESONANCE ANGIOGRAPHY
  • RENAL-ALLOGRAFT REJECTION
  • ACUTE KIDNEY INJURY
  • DIFFUSION-WEIGHTED MRI
  • ACUTE TUBULAR-NECROSIS
  • DELAYED GRAFT FUNCTION
  • STEADY-STATE
  • IN-VIVO
  • VASCULAR COMPLICATIONS
  • NONINVASIVE ASSESSMENT

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