Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp, Lifelines Cohort

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35 Citations (Scopus)

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Original languageEnglish
Pages (from-to)636-+
Number of pages16
JournalNature Genetics
Volume51
Issue number4
DOIs
Publication statusPublished - Apr-2019

Keywords

  • ENVIRONMENT INTERACTION
  • GENOTYPE IMPUTATION
  • NICOTINE METABOLISM
  • RISK LOCI
  • METAANALYSIS
  • ARCHITECTURE
  • CHOLESTEROL
  • CIGARETTES
  • VARIANTS
  • SUSCEPTIBILITY

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