Multi-institutional comparison of volumetric modulated arc therapy vs. intensity-modulated radiation therapy for head-and-neck cancer: a planning study

Andrea Holt, Dirk Van Gestel, Mark P. Arends, Erik W. Korevaar, Danny Schuring, Martina C. Kunze-Busch, Rob J. W. Louwe, Corine van Vliet-Vroegindeweij*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Background: Compared to static beam Intensity-Modulated Radiation Therapy (IMRT), the main advantage of Volumetric Modulated Arc Therapy (VMAT) is a shortened delivery time, which leads to improved patient comfort and possibly smaller intra-fraction movements. This study aims at a treatment planner-independent comparison of radiotherapy treatment planning of IMRT and VMAT for head-and-neck cancer performed by several institutes and based on the same CT- and contouring data.

    Methods: Five institutes generated IMRT and VMAT plans for five oropharyngeal cancer patients using either Pinnacle(3) or Oncentra Masterplan to be delivered on Elekta linear accelerators.

    Results: Comparison of VMAT and IMRT plans within the same patient and institute showed significantly better sparing for almost all OARs with VMAT. The average mean dose to the parotid glands and oral cavity was reduced from 27.2 Gy and 39.4 Gy for IMRT to 25.0 Gy and 36.7 Gy for VMAT, respectively. The dose conformity at 95% of the prescribed dose for PTVboost and PTVtotal was 1.45 and 1.62 for IMRT and 1.37 and 1.50 for VMAT, respectively. The average effective delivery time was reduced from 13: 15 min for IMRT to 5: 54 min for VMAT.

    Conclusions: Independently of institution-specific optimization strategies, the quality of the VMAT plans including double arcs was superior to step-and-shoot IMRT plans including 5-9 beam ports, while the effective treatment delivery time was shortened by similar to 50% with VMAT.

    Original languageEnglish
    Article number26
    Number of pages11
    JournalRadiation oncology
    Publication statusPublished - 31-Jan-2013


    • Head-and-neck cancer
    • Simultaneous integrated boost
    • Volumetric modulated arc therapy
    • Intensity-modulated radiation therapy
    • Multi-institutional collaboration
    • SmartArc
    • IMRT

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