Multi-omics approaches to understand respiratory disease

    Research output: ThesisThesis fully internal (DIV)

    96 Downloads (Pure)

    Abstract

    The main scope of this thesis is to improve our understanding of the biological mechanisms of allergic disease, in particular asthma and rhinitis, by applying multi-omics approaches. We collected multi-omics data from the genome, epigenome, bulk and single-cell transcriptome, and the exposome. By applying association and machine learning approaches, we investigated epigenetic mechanisms of the development of allergic disease, revealed cell-type specific molecular regulation of asthma risk variants, identified biomarkers of allergy, and provided a prediction tool for allergic disease.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Koppelman, Gerard, Supervisor
    • Xu, Chengjian, Co-supervisor
    Award date15-Sep-2021
    Place of Publication[Groningen]
    Publisher
    DOIs
    Publication statusPublished - 2021

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