Multifactorial Diseases of the Heart, Kidneys, Lungs, and Liver and Incident Cancer: Epidemiology and Shared Mechanisms

Canxia Shi, Sanne de Wit, Emina Učambarlić, George Markousis-Mavrogenis, Elles M. Screever, Wouter C. Meijers, Rudolf A. de Boer*, Joseph Pierre Aboumsallem*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
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Within the aging population, the frequency of cancer is increasing dramatically. In addition, multiple genetic and environmental factors lead to common multifactorial diseases, including cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease, and metabolic-associated fatty liver disease. In recent years, there has been a growing awareness of the connection between cancer and multifactorial diseases, as well as how one can affect the other, resulting in a vicious cycle. Although the exact mechanistic explanations behind this remain to be fully explored, some progress has been made in uncovering the common pathologic mechanisms. In this review, we focus on the nature of the link between cancer and common multifactorial conditions, as well as specific shared mechanisms, some of which may represent either preventive or therapeutic targets. Rather than organ-specific interactions, we herein focus on the shared mechanisms among the multifactorial diseases, which may explain the increased cancer risk. More research on this subject will highlight the significance of developing new drugs that target multiple systems rather than just one disease.

Original languageEnglish
Article number729
Number of pages20
Issue number3
Publication statusPublished - Feb-2023


  • cardio-oncology
  • chronic obstructive pulmonary disease
  • end-stage renal disease
  • heart failure
  • incident cancer
  • metabolic associated fatty liver disease
  • onco-nephrology
  • reverse cardio-oncology

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