Multimodality Imaging in the Diagnostic Work-Up of Endocarditis and Cardiac Implantable Electronic Device (CIED) Infection

Nicola Galea*, Francesco Bandera, Chiara Lauri, Camillo Autore, Andrea Laghi, Paola Anna Erba

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

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    Abstract

    Infective endocarditis (IE) is a serious cardiac condition, which includes a wide range of clinical presentations, with varying degrees of severity. The diagnosis is multifactorial and a proper characterization of disease requires the identification of the primary site of infection (usually the cardiac valve) and the search of secondary systemic complications. Early depiction of local complications or distant embolization has a great impact on patient management and prognosis, as it may induce to aggressive antibiotic treatment or, in more advanced cases, cardiac surgery. In this setting, the multimodality imaging has assumed a pivotal role in the clinical decision making and it requires the physician to be aware of the advantages and disadvantages of each imaging technique. Echocardiography is the first imaging test, but it has several limitations. Therefore, the integration with other imaging modalities (computed tomography, magnetic resonance imaging, nuclear imaging) becomes often necessary. Different strategies should be applied depending on whether the infection is suspected or already ascertained, whether located in native or prosthetic valves, in the left or right chambers, or if it involves an implanted cardiac device. In addition, detection of extracardiac IE-related lesions is crucial for a correct management and treatment. The aim of this review is to illustrate strengths and weaknesses of the various methods in the most common clinical scenarios.

    Original languageEnglish
    Article number2237
    Number of pages23
    JournalJournal of Clinical Medicine
    Volume9
    Issue number7
    DOIs
    Publication statusPublished - Jul-2020

    Keywords

    • Infective endocarditis
    • echocardiography
    • multimodality imaging
    • computed tomography
    • magnetic resonance imaging
    • nuclear imaging
    • positron emission tomography
    • endocarditis team
    • EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY
    • PROSTHETIC VALVE ENDOCARDITIS
    • CONGENITAL HEART-DISEASE
    • F-18-FDG PET/CT
    • DUKE CRITERIA
    • TRANSESOPHAGEAL ECHOCARDIOGRAPHY
    • COMPUTED-TOMOGRAPHY
    • RISK-FACTORS
    • DRUG-USERS
    • CT

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