Multimorbidity in psychotic disorders and their unaffected siblings: An epidemiological perspective

M.F. Khan; M.A. Islam; P.J. Quee; H. Snieder; E.R. Van Den Heuvel; R. Bruggeman; B.Z. Alizadeh

doi:10.1007/s00406-013-0433-0

Multimorbidity in psychotic disorders and their unaffected siblings: An epidemiological perspective

M.F. Khan, M.A. Islam, P.J. Quee, H. Snieder, E.R. Van Den Heuvel, R. Bruggeman, B.Z. Alizadeh

Research output: Contribution to conference › Abstract › Academic

8 Citations (Scopus)

Abstract

Objective: Multimorbidity, the prevalence of two or more diseases within the same individual, imposes overwhelming burden in patients with psychotic disorders. Its prevalence has been estimated higher compared to normal populations, but systematic studies are lacking. In addition, no studies have investigated the role of familial factors associated with multimorbidity in psychosis. We aimed to study the epidemiology of multimorbidity in patients with psychotic disorders, and their relatives. Methods: The study was performed within the framework of the longitudinal cohort study Genetic Risk and Outcome of Psychosis (GROUP). Data of 1,024 patients (predominantly with schizophrenia), 994 unaffected siblings and 566 controls were compared on prevalence of lifetime diseases (4 psychiatric, 117 somatic), and self-reported complaints. Arandomeffect modelwas used to investigate the effect of gender (female, male) and age category (>40, 21-40, and

Original language	English
Pages	61-62
Number of pages	2
DOIs	https://doi.org/10.1007/s00406-013-0433-0
Publication status	Published - 1-Sept-2013

Keywords

sibling
schizophrenia
psychosis
human
patient
prevalence
diseases
gender
lifespan
epidemiology
population
genetic risk
cohort analysis
male
female

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title = "Multimorbidity in psychotic disorders and their unaffected siblings: An epidemiological perspective",

abstract = "Objective: Multimorbidity, the prevalence of two or more diseases within the same individual, imposes overwhelming burden in patients with psychotic disorders. Its prevalence has been estimated higher compared to normal populations, but systematic studies are lacking. In addition, no studies have investigated the role of familial factors associated with multimorbidity in psychosis. We aimed to study the epidemiology of multimorbidity in patients with psychotic disorders, and their relatives. Methods: The study was performed within the framework of the longitudinal cohort study Genetic Risk and Outcome of Psychosis (GROUP). Data of 1,024 patients (predominantly with schizophrenia), 994 unaffected siblings and 566 controls were compared on prevalence of lifetime diseases (4 psychiatric, 117 somatic), and self-reported complaints. Arandomeffect modelwas used to investigate the effect of gender (female, male) and age category (>40, 21-40, and",

keywords = "sibling, schizophrenia, psychosis, human, patient, prevalence, diseases, gender, lifespan, epidemiology, population, genetic risk, cohort analysis, male, female",

author = "M.F. Khan and M.A. Islam and P.J. Quee and H. Snieder and {Van Den Heuvel}, E.R. and R. Bruggeman and B.Z. Alizadeh",

year = "2013",

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doi = "10.1007/s00406-013-0433-0",

language = "English",

pages = "61--62",

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T1 - Multimorbidity in psychotic disorders and their unaffected siblings: An epidemiological perspective

AU - Khan, M.F.

AU - Islam, M.A.

AU - Quee, P.J.

AU - Snieder, H.

AU - Van Den Heuvel, E.R.

AU - Bruggeman, R.

AU - Alizadeh, B.Z.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Objective: Multimorbidity, the prevalence of two or more diseases within the same individual, imposes overwhelming burden in patients with psychotic disorders. Its prevalence has been estimated higher compared to normal populations, but systematic studies are lacking. In addition, no studies have investigated the role of familial factors associated with multimorbidity in psychosis. We aimed to study the epidemiology of multimorbidity in patients with psychotic disorders, and their relatives. Methods: The study was performed within the framework of the longitudinal cohort study Genetic Risk and Outcome of Psychosis (GROUP). Data of 1,024 patients (predominantly with schizophrenia), 994 unaffected siblings and 566 controls were compared on prevalence of lifetime diseases (4 psychiatric, 117 somatic), and self-reported complaints. Arandomeffect modelwas used to investigate the effect of gender (female, male) and age category (>40, 21-40, and

AB - Objective: Multimorbidity, the prevalence of two or more diseases within the same individual, imposes overwhelming burden in patients with psychotic disorders. Its prevalence has been estimated higher compared to normal populations, but systematic studies are lacking. In addition, no studies have investigated the role of familial factors associated with multimorbidity in psychosis. We aimed to study the epidemiology of multimorbidity in patients with psychotic disorders, and their relatives. Methods: The study was performed within the framework of the longitudinal cohort study Genetic Risk and Outcome of Psychosis (GROUP). Data of 1,024 patients (predominantly with schizophrenia), 994 unaffected siblings and 566 controls were compared on prevalence of lifetime diseases (4 psychiatric, 117 somatic), and self-reported complaints. Arandomeffect modelwas used to investigate the effect of gender (female, male) and age category (>40, 21-40, and

KW - sibling

KW - schizophrenia

KW - psychosis

KW - human

KW - patient

KW - prevalence

KW - diseases

KW - gender

KW - lifespan

KW - epidemiology

KW - population

KW - genetic risk

KW - cohort analysis

KW - male

KW - female

U2 - 10.1007/s00406-013-0433-0

DO - 10.1007/s00406-013-0433-0

M3 - Abstract

SP - 61

EP - 62

ER -

Multimorbidity in psychotic disorders and their unaffected siblings: An epidemiological perspective

Abstract

Keywords

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