Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

Ming-San Ma; Nieske Brouwer; Evelyn Wesseling; Divya Raj; Johannes van der Want; Erik Boddeke; Veerakumar Balasubramaniyan; Sjef Copray

doi:10.1016/j.mcn.2015.02.002

Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

Ming-San Ma, Nieske Brouwer, Evelyn Wesseling, Divya Raj , Johannes van der Want, Erik Boddeke, Veerakumar Balasubramaniyan, Sjef Copray^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs. (C) 2015 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	21-30
Number of pages	10
Journal	Molecular and Cellular Neuroscience
Volume	65
DOIs	https://doi.org/10.1016/j.mcn.2015.02.002
Publication status	Published - Mar-2015

Keywords

Tanycytes
Neurogenesis
Neural stem cells
Hypothalamus
Third ventricle
Nestin
FIBRILLARY ACIDIC PROTEIN
CENTRAL-NERVOUS-SYSTEM
PROGENITOR CELLS
ENERGY-BALANCE
NEUROGENESIS
BRAIN
NEURONS
DIFFERENTIATION
ASTROCYTES
MECHANISM

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@article{cbd22588a74e4951967810cd8ed341dc,

title = "Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus",

abstract = "The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs. (C) 2015 Elsevier Inc. All rights reserved.",

keywords = "Tanycytes, Neurogenesis, Neural stem cells, Hypothalamus, Third ventricle, Nestin, FIBRILLARY ACIDIC PROTEIN, CENTRAL-NERVOUS-SYSTEM, PROGENITOR CELLS, ENERGY-BALANCE, NEUROGENESIS, BRAIN, NEURONS, DIFFERENTIATION, ASTROCYTES, MECHANISM",

author = "Ming-San Ma and Nieske Brouwer and Evelyn Wesseling and Divya Raj and {van der Want}, Johannes and Erik Boddeke and Veerakumar Balasubramaniyan and Sjef Copray",

year = "2015",

month = mar,

doi = "10.1016/j.mcn.2015.02.002",

language = "English",

volume = "65",

pages = "21--30",

journal = "Molecular and Cellular Neuroscience",

issn = "1044-7431",

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TY - JOUR

T1 - Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

AU - Ma, Ming-San

AU - Brouwer, Nieske

AU - Wesseling, Evelyn

AU - Raj , Divya

AU - van der Want, Johannes

AU - Boddeke, Erik

AU - Balasubramaniyan, Veerakumar

AU - Copray, Sjef

PY - 2015/3

Y1 - 2015/3

N2 - The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs. (C) 2015 Elsevier Inc. All rights reserved.

AB - The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs. (C) 2015 Elsevier Inc. All rights reserved.

KW - Tanycytes

KW - Neurogenesis

KW - Neural stem cells

KW - Hypothalamus

KW - Third ventricle

KW - Nestin

KW - FIBRILLARY ACIDIC PROTEIN

KW - CENTRAL-NERVOUS-SYSTEM

KW - PROGENITOR CELLS

KW - ENERGY-BALANCE

KW - NEUROGENESIS

KW - BRAIN

KW - NEURONS

KW - DIFFERENTIATION

KW - ASTROCYTES

KW - MECHANISM

U2 - 10.1016/j.mcn.2015.02.002

DO - 10.1016/j.mcn.2015.02.002

M3 - Article

SN - 1044-7431

VL - 65

SP - 21

EP - 30

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

ER -