Multivalent Noncovalent Interfacing and Cross-Linking of Supramolecular Tubes

Fangyuan Xiu, Anamarija Knežević, Supaporn Kwangmettatam, Daniele Di Iorio, Jurriaan Huskens, Tibor Kudernac*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
48 Downloads (Pure)


Natural supramolecular filaments have the ability to cross-link with each other and to interface with the cellular membrane via biomolecular noncovalent interactions. This behavior allows them to form complex networks within as well as outside the cell, i.e., the cytoskeleton and the extracellular matrix, respectively. The potential of artificial supramolecular polymers to interact through specific noncovalent interactions has so far only seen limited exploration due to the dynamic nature of supramolecular interactions. Here, a system of synthetic supramolecular tubes that cross-link forming supramolecular networks, and at the same time bind to biomimetic surfaces by the aid of noncovalent streptavidin–biotin linkages, is demonstrated. The architecture of the networks can be engineered by controlling the density of the biotin moiety at the exterior of the tubes as well as by the concentration of the streptavidin. The presented strategy provides a pathway for designing adjustable artificial supramolecular superstructures, which can potentially yield more complex biomimetic adaptive materials.

Original languageEnglish
Article number2105926
Number of pages11
JournalAdvanced materials
Issue number5
Early online date25-Nov-2021
Publication statusPublished - 3-Feb-2022


  • chiral tubes
  • cross-linking
  • streptavidin–biotin interactions
  • supramolecular networks
  • supramolecular polymers
  • surface binding

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