Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells

Marloes van Zwam, Annet F. Wierenga-Wolf, Marie-Jose Melief, Benjamin Schrijver, Jon D. Laman*, Leonie A. Boven

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Myelin-laden macrophages reside within the CNS, the CSF and in the CNS-draining lymph nodes during MS and EAE, suggesting migration of these macrophages between these compartments and interaction with other cells. Since chemokines and their receptors are pivotal for leukocyte trafficking, we addressed whether myelin ingestion affects chemotaxis of mouse macrophages in vitro. Myelin ingestion enhanced expression of CCR7 and CXCR3 on macrophages and migration towards CCL21 and CXCL10. Furthermore, myelin-laden macrophages released chemoattractants resulting in enhanced migration of myeloid cells in vitro. Our data demonstrate that myelin-laden macrophages have increased motility and suggest trafficking between anatomical compartments in vivo. (C) 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalJournal of Neuroimmunology
Volume225
Issue number1-2
DOIs
Publication statusPublished - 25-Aug-2010
Externally publishedYes

Keywords

  • Macrophages
  • Cervical lymph nodes
  • Multiple sclerosis
  • Immune cell trafficking
  • Cerebrospinal fluid
  • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
  • CENTRAL-NERVOUS-SYSTEM
  • MULTIPLE-SCLEROSIS LESIONS
  • CEREBROSPINAL-FLUID
  • IN-VITRO
  • T-CELLS
  • CHEMOKINE RECEPTORS
  • VIRUS ENCEPHALITIS
  • ENDOTHELIAL-CELLS
  • BETA-CHEMOKINES

Cite this