Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388

RM de Jong; Antoon T. M.  Willemsen; RHJA Slart; PK Blanksma; A van Waarde; JH Cornel; W Vaalburg; DJ van Veldhuisen; PH Elsinga

doi:10.1007/s00259-004-1701-z

Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388

RM de Jong, Antoon T. M. Willemsen, RHJA Slart, PK Blanksma, A van Waarde, JH Cornel, W Vaalburg, DJ van Veldhuisen, PH Elsinga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose. The beta-adrenoceptor (beta-AR) plays an important role in heart failure. Recently, the new tracer (S)-[C-11]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac beta-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial beta-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[C-11]CGP12388 PET.

Methods. Myocardial beta-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[C-11]CGP12388 PET.

Results. beta-AR densities of 5.4 +/- 1.3 pmol/g (mean +/- SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4 +/- 1.5 pmol/g, p <0.005).

Conclusion. This study indicates that PET with (S)-[C-11]CGP12388 is applicable for the measurement of myocardial beta-AR density in patients. A highly significant reduction in beta-AR density was found in patients with IDC compared with healthy controls.

Original language	English
Pages (from-to)	443-447
Number of pages	5
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	32
Issue number	4
DOIs	https://doi.org/10.1007/s00259-004-1701-z
Publication status	Published - Apr-2005

Keywords

imaging
beta-adrenergic receptors
heart failure
POSITRON-EMISSION-TOMOGRAPHY
CHRONIC HEART-FAILURE
ADRENERGIC-RECEPTOR DENSITY
MODEL
(S)-<C-11>CGP12388
ECHOCARDIOGRAPHY
CATECHOLAMINES
CGP-12177
LIGAND

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de Jong, RM., Willemsen, A. T. M., Slart, RHJA., Blanksma, PK., van Waarde, A., Cornel, JH., Vaalburg, W., van Veldhuisen, DJ., & Elsinga, PH. (2005). Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388. European Journal of Nuclear Medicine and Molecular Imaging, 32(4), 443-447. https://doi.org/10.1007/s00259-004-1701-z

@article{7cb1b8aa7dee45f7afbd227a45a71052,

title = "Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388",

abstract = "Purpose. The beta-adrenoceptor (beta-AR) plays an important role in heart failure. Recently, the new tracer (S)-[C-11]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac beta-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial beta-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[C-11]CGP12388 PET.Methods. Myocardial beta-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[C-11]CGP12388 PET.Results. beta-AR densities of 5.4 +/- 1.3 pmol/g (mean +/- SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4 +/- 1.5 pmol/g, p <0.005).Conclusion. This study indicates that PET with (S)-[C-11]CGP12388 is applicable for the measurement of myocardial beta-AR density in patients. A highly significant reduction in beta-AR density was found in patients with IDC compared with healthy controls.",

keywords = "imaging, beta-adrenergic receptors, heart failure, POSITRON-EMISSION-TOMOGRAPHY, CHRONIC HEART-FAILURE, ADRENERGIC-RECEPTOR DENSITY, MODEL, (S)-<C-11>CGP12388, ECHOCARDIOGRAPHY, CATECHOLAMINES, CGP-12177, LIGAND",

author = "{de Jong}, RM and Willemsen, {Antoon T. M.} and RHJA Slart and PK Blanksma and {van Waarde}, A and JH Cornel and W Vaalburg and {van Veldhuisen}, DJ and PH Elsinga",

year = "2005",

month = apr,

doi = "10.1007/s00259-004-1701-z",

language = "English",

volume = "32",

pages = "443--447",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer",

number = "4",

}

de Jong, RM, Willemsen, ATM , Slart, RHJA, Blanksma, PK, van Waarde, A, Cornel, JH, Vaalburg, W, van Veldhuisen, DJ & Elsinga, PH 2005, 'Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388', European Journal of Nuclear Medicine and Molecular Imaging, vol. 32, no. 4, pp. 443-447. https://doi.org/10.1007/s00259-004-1701-z

Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388. / de Jong, RM; Willemsen, Antoon T. M. ; Slart, RHJA et al.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 32, No. 4, 04.2005, p. 443-447.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388

AU - de Jong, RM

AU - Willemsen, Antoon T. M.

AU - Slart, RHJA

AU - Blanksma, PK

AU - van Waarde, A

AU - Cornel, JH

AU - Vaalburg, W

AU - van Veldhuisen, DJ

AU - Elsinga, PH

PY - 2005/4

Y1 - 2005/4

N2 - Purpose. The beta-adrenoceptor (beta-AR) plays an important role in heart failure. Recently, the new tracer (S)-[C-11]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac beta-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial beta-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[C-11]CGP12388 PET.Methods. Myocardial beta-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[C-11]CGP12388 PET.Results. beta-AR densities of 5.4 +/- 1.3 pmol/g (mean +/- SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4 +/- 1.5 pmol/g, p <0.005).Conclusion. This study indicates that PET with (S)-[C-11]CGP12388 is applicable for the measurement of myocardial beta-AR density in patients. A highly significant reduction in beta-AR density was found in patients with IDC compared with healthy controls.

AB - Purpose. The beta-adrenoceptor (beta-AR) plays an important role in heart failure. Recently, the new tracer (S)-[C-11]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac beta-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial beta-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[C-11]CGP12388 PET.Methods. Myocardial beta-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[C-11]CGP12388 PET.Results. beta-AR densities of 5.4 +/- 1.3 pmol/g (mean +/- SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4 +/- 1.5 pmol/g, p <0.005).Conclusion. This study indicates that PET with (S)-[C-11]CGP12388 is applicable for the measurement of myocardial beta-AR density in patients. A highly significant reduction in beta-AR density was found in patients with IDC compared with healthy controls.

KW - imaging

KW - beta-adrenergic receptors

KW - heart failure

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - CHRONIC HEART-FAILURE

KW - ADRENERGIC-RECEPTOR DENSITY

KW - MODEL

KW - (S)-<C-11>CGP12388

KW - ECHOCARDIOGRAPHY

KW - CATECHOLAMINES

KW - CGP-12177

KW - LIGAND

U2 - 10.1007/s00259-004-1701-z

DO - 10.1007/s00259-004-1701-z

M3 - Article

SN - 1619-7070

VL - 32

SP - 443

EP - 447

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 4

ER -

Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[C-11]CGP12388

Abstract

Keywords

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