Myopia as a Risk Factor for Open-Angle Glaucoma: A Systematic Review and Meta-Analysis

Michael W. Marcus, Margriet M. de Vries, Francisco G. Junoy Montolio, Nomdo M. Jansonius*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    276 Citations (Scopus)

    Abstract

    Objective: To determine the association between myopia and open-angle glaucoma.

    Design: Systematic review and meta-analysis of observational studies.

    Participants: Thirteen studies involving 48 161 individuals.

    Methods: Articles published between 1994 and 2010 were identified in PubMed, Embase, and reference lists. Study-specific odds ratios (ORs) were pooled using a random effects model.

    Main Outcome Measures: Odds ratios with 95% confidence intervals (CIs) of myopia as a risk factor for open-angle glaucoma.

    Results: Data from 11 population-based cross-sectional studies were included in the main analyses. The pooled OR of the association between myopia and glaucoma based on 11 risk estimates was 1.92 (95% CI, 1.54-2.38). On the basis of 7 risk estimates, the pooled ORs of the associations between low myopia (myopia up to -3 D) and glaucoma and between high myopia (

    Conclusions: Individuals with myopia have an increased risk of developing open-angle glaucoma. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2011;118:1989-1994 (C) 2011 by the American Academy of Ophthalmology.

    Original languageEnglish
    Pages (from-to)1989-U146
    Number of pages8
    JournalOphthalmology
    Volume118
    Issue number10
    DOIs
    Publication statusPublished - Oct-2011

    Keywords

    • LOW-TENSION GLAUCOMA
    • VISUAL-FIELD LOSS
    • REFRACTIVE ERRORS
    • OCULAR HYPERTENSION
    • PUBLICATION BIAS
    • ADULT CHINESE
    • EYE
    • POPULATION
    • PREVALENCE
    • SUSCEPTIBILITY

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