TY - JOUR
T1 - N-Dealkylation of Amines
AU - Najmi, Ali Alipour
AU - Bischoff, Rainer
AU - Permentier, Hjalmar P.
N1 - Funding Information:
Funding: This work is part of the Open Technology Programme of Toegepaste en Technische Wetenschappen (TTW) with project number 15230 which is financed by the Netherlands Organisation for Scientific Research (NWO).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agro-chemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. In this review, different approaches for the N-dealkylation of amines including chemical, catalytic, electro-chemical, photochemical and enzymatic methods will be discussed.
AB - N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agro-chemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. In this review, different approaches for the N-dealkylation of amines including chemical, catalytic, electro-chemical, photochemical and enzymatic methods will be discussed.
KW - drug metabolite
KW - N-dealkylation
KW - opiate alkaloids
KW - tropane alkaloids
UR - http://www.scopus.com/inward/record.url?scp=85130722415&partnerID=8YFLogxK
U2 - 10.3390/molecules27103293
DO - 10.3390/molecules27103293
M3 - Article
C2 - 35630770
AN - SCOPUS:85130722415
SN - 1431-5157
VL - 27
JO - Molecules
JF - Molecules
IS - 10
M1 - 3293
ER -