N-METHYLADRENALINE - AGE-DEPENDENT URINARY-EXCRETION, PERINATAL ORGAN CONTENT AND RELATION WITH CLASSICAL CATECHOLAMINES

IP KEMA*, CJF SCHOOTS, CEM GIDDING, A OKKEN, JG AARNOUDSE, FAJ MUSKIET

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Using high performance liquid chromatography with electrochemical detection we determined free dopamine, noradrenaline, adrenaline and N-methyladrenaline in: (1) urines from newborns (n=32), children (n=45) and adults (n=19) and (2) adrenals, organ of Zuckerkandl, dorsal roots and perirenal brown adipose tissue from deceased fetuses (n=2), very premature (n=6) and term (n=2) newborns and infants (n=2). Data from children and adults showed that contributions of adrenaline and N-methyladrenaline to the sum of urinary free catecholamines increase with age, Relative amounts of adrenaline and N-methyladrenaline increased in both adrenal and extra adrenal chromaffin tissues from late gestation up to several months of postnatal life. Increase of adrenal N-methyladrenaline content follows endocrine maturation of the medulla, phenylethanolamine-N-methyltransferase induction and subsequent adrenaline synthesis. Relative amounts of N-methyladrenaline in extra adrenal chromaffin tissue increase in a period that is associated with its regression. Further investigations are necessary to elucidate the function and possible clinical chemical usefulness of N-methyladrenaline.

Original languageEnglish
Pages (from-to)137-150
Number of pages14
JournalClinica chimica acta
Volume238
Issue number2
Publication statusPublished - 14-Jul-1995

Keywords

  • ADRENALINE
  • PHENYLETHANOLAMINE-N-METHYLTRANSFERASE
  • EXTRA ADRENAL CHROMAFFIN TISSUE
  • HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
  • AMPEROMETRIC DETECTION
  • LIQUID-CHROMATOGRAPHY
  • EPINEPHRINE SYNTHESIS
  • METABOLITES
  • DOPAMINE
  • NOREPINEPHRINE
  • CHILDREN
  • PLASMA
  • URINES
  • ACID

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