Nanostructured multifunctional stimuli-responsive glycopolypeptide-based copolymers for biomedical applications

Mahsa Sedighi, Zahra Mahmoudi, Alireza Ghasempour, Mehdi Shakibaie, Fahimeh Ghasemi, Mahsa Akbari, Samin Abbaszadeh, Ebrahim Mostafavi, Hélder A. Santos*, Mohammad-Ali Shahbazi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Inspired by natural resources, such as peptides and carbohydrates, glycopolypeptide biopolymer has recently emerged as a new form of biopolymer being recruited in various biomedical applications. Glycopolypeptides with well-defined secondary structures and pendant glycosides on the polypeptide backbone have sparked lots of research interest and they have an innate ability to self-assemble in diverse structures. The nanostructures of glycopolypeptides have also opened up new perspectives in biomedical applications due to their stable three-dimensional structures, high drug loading efficiency, excellent biocompatibility, and biodegradability. Although the development of glycopolypeptide-based nanocarriers is well-studied, their clinical translation is still limited. The present review highlights the preparation and characterization strategies related to glycopolypeptides-based copolymers, followed by a comprehensive discussion on their biomedical applications with a specific focus on drug delivery by various stimuli-responsive (e.g., pH, redox, conduction, and sugar) nanostructures, as well as their beneficial usage in diagnosis and regenerative medicine.
Original languageEnglish
Pages (from-to)128-145
Number of pages18
JournalJournal of Controlled Release
Early online date6-Jan-2023
Publication statusPublished - Feb-2023


  • Glycopolypeptide
  • Nanocarriers
  • Drug delivery
  • Regenerative medicine
  • Self-assembly

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