Nasal high flow therapy and PtCO2 in stable COPD: A randomized controlled cross-over trial

Steven McKinstry*, Janine Pilcher, George Bardsley, James Berry, Susanne Van de Hei, Irene Braithwaite, James Fingleton, Mark Weatherall, Richard Beasley

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Background and objectiveHypercapnia is associated with worse clinical outcomes in exacerbations of COPD. The present study aimed to determine the effects of nasal high flow (NHF) therapy on transcutaneous partial pressure of carbon dioxide (PtCO2) in stable COPD patients.

    MethodsIn a single-blind randomized controlled cross-over trial, 48 participants with COPD were allocated in random order to all of four 20 min interventions: NHF at 15 L/min, 30 L/min and 45 L/min or breathing room air with each intervention followed by a washout period of 15 min. The primary outcome measure was PtCO2 at 20 min, adjusted for baseline PtCO2. Secondary outcomes included respiratory rate at 20 min, adjusted for baseline.

    ResultsThe mean (95% CI) change in PtCO2 at 20 min was -0.6 mm Hg (-1.1 to 0.0), P = 0.06; -1.3 mm Hg (-1.9 to 0.8), P <0.001; and -2.4 mm Hg (-2.9 to -1.8), P <0.001; for NHF at 15 L/min, 30 L/min and 45 L/min compared with room air, respectively. The mean (95% CI) change in respiratory rate at 20 min was -1.5 (-2.7 to -0.3), P = 0.02; -4.1 (-5.3 to -2.9), P <0.001; and -4.3 (-5.5 to -3.1), P <0.001; breaths per minute compared with room air, respectively.

    ConclusionNHF results in a small flow-dependent reduction in PtCO2 and respiratory rate in patients with stable COPD.

    Original languageEnglish
    Pages (from-to)378-384
    Number of pages7
    JournalRespirology
    Volume23
    Issue number4
    DOIs
    Publication statusPublished - Apr-2018

    Keywords

    • arterial partial pressure
    • carbon dioxide
    • chronic obstructive respiratory disease
    • nasal high flow
    • randomized controlled trial
    • OBSTRUCTIVE PULMONARY-DISEASE
    • ACUTE RESPIRATORY-FAILURE
    • OXYGEN-THERAPY
    • CARBON-DIOXIDE
    • NONINVASIVE VENTILATION
    • BREATHING PATTERN
    • EXACERBATIONS
    • PRESSURES
    • CANNULAE
    • ADULTS

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