National screening program vs. standardized neurodevelopmental follow-up

Cornelia Maschke*, Birte Ellenrieder, Kurt Hecher, Peter Bartmann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)


Background: Long-term follow-up is urgently needed to decide on the consequences of new therapies.

Objective: This study assesses the use of a national child development screening program for a follow-up examination of a defined patient group.

Patients and methods: Neurodevelopmental outcome of 139 survivors after intrauterine laser coagulation for severe twin-twin transfusion syndrome was investigated both according to a standardized neurodevelopmental follow-up and according to the pediatricians' screening examinations.

Results: Screening and standardized tests revealed identical results in 90.6% of the cases. Using the national screening program only four out of 139 children (2.9%) with minor neurological disabilities would have been missed. For identifying mild or severe neurodevelopmental abnormalities the screening has a sensivity of 78% and a specifity of 93%. The positive predictive value is 61% and the negative predictive value 97%.

Conclusions: The use of already available and established follow-up programs for extended follow-up studies would considerably reduce costs, time and manpower.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalJournal of Perinatal Medicine
Issue number1
Publication statusPublished - Jan-2009


  • Laser coagulation
  • neurodevelopmental follow-up
  • preterm infant
  • screening examinations
  • twin-twin transfusion syndrome

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