TY - JOUR
T1 - Natural and bioinspired excipients for dry powder inhalation formulations
AU - Zillen, Daan
AU - Beugeling, Max
AU - Hinrichs, Wouter L.J.
AU - Frijlink, Henderik W.
AU - Grasmeijer, Floris
N1 - Funding Information:
Daan Zillen gratefully acknowledges the financial support of DFE Pharma GmbH & Co. KG for his doctorate track. All figures were created with BioRender.com .
Publisher Copyright:
© 2021 The Authors
PY - 2021/12
Y1 - 2021/12
N2 - Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such dry powder inhalation formulations generally include natural and bio-inspired excipients, which, among other purposes, are used to improve dosing reproducibility and aerosolization performance. Amino acids can enhance powder dispersibility and provide protection against moisture uptake. Sugars are used as drug-carrying diluents, stabilizers for biopharmaceuticals, and surface enrichers. Lipids and lipid-like excipients can reduce interparticle adhesive forces and are also used as constituents of liposomal drug delivery systems. Finally, biodegradable polymers are used to facilitate sustained release and targeted drug delivery. Despite their promise, pulmonary toxicity of many of the discussed excipients remains largely unknown and requires attention in future research.
AB - Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such dry powder inhalation formulations generally include natural and bio-inspired excipients, which, among other purposes, are used to improve dosing reproducibility and aerosolization performance. Amino acids can enhance powder dispersibility and provide protection against moisture uptake. Sugars are used as drug-carrying diluents, stabilizers for biopharmaceuticals, and surface enrichers. Lipids and lipid-like excipients can reduce interparticle adhesive forces and are also used as constituents of liposomal drug delivery systems. Finally, biodegradable polymers are used to facilitate sustained release and targeted drug delivery. Despite their promise, pulmonary toxicity of many of the discussed excipients remains largely unknown and requires attention in future research.
KW - Bioinspired excipients
KW - Drug formulation
KW - dry powder inhalation
KW - Natural excipients
KW - Pulmonary drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85113950032&partnerID=8YFLogxK
U2 - 10.1016/j.cocis.2021.101497
DO - 10.1016/j.cocis.2021.101497
M3 - Review article
AN - SCOPUS:85113950032
SN - 1359-0294
VL - 56
JO - Current Opinion in Colloid and Interface Science
JF - Current Opinion in Colloid and Interface Science
M1 - 101497
ER -