Natural compounds as a source of protein tyrosine phosphatase inhibitors: Application to the rational design of small-molecule derivatives

Carmen V. Ferreira*, Giselle Z. Justo, Ana C. S. Souza, Karla C. S. Queiroz, William F. Zambuzzi, Hiroshi Aoyama, Maikel P. Peppelenbosch

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    45 Citations (Scopus)

    Abstract

    Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events. Protein tyrosine kinases and protein tyrosine phosphatases (PTPs) have a pivotal role in regulating both normal cell physiology and pathophysiology. Accordingly, deregulated activity of both protein tyrosine kinases and PTPs is involved in the development of numerous congenitically inherited and acquired human diseases, prompting obvious pharmaceutical and academic research interest. The development of compound libraries with higher selective PTP inhibitory activity has been bolstered by the realization that many natural products have such activity and thus are interesting biologically lead compounds, which properties are widely exploited. In addition, more rational approaches have focused on the incorporation of phosphotyrosine mimetics into specific peptide templates (peptidomimetic backbones). Additional factors furthering discovery as well as therapeutic application of new bioactive molecules are the integration of functional genomics, cell biology, structural biology, drug design, molecular screening and chemical diversity. Together, all these factors will lead to new avenues to treat clinical disease based on PTP inhibition. (c) 2006 Elsevier Masson SAS. All rights reserved.

    Original languageEnglish
    Pages (from-to)1859-1873
    Number of pages15
    JournalBIOCHIMIE
    Volume88
    Issue number12
    DOIs
    Publication statusPublished - Dec-2006

    Keywords

    • protein tyrosine phosphatases
    • PTP inhibitors
    • natural compounds
    • peptidomimetics
    • GROWTH IN-VITRO
    • DUAL-SPECIFICITY PHOSPHATASE
    • SOLID-PHASE SYNTHESIS
    • INSULIN-RECEPTOR
    • SUBSTRATE-SPECIFICITY
    • PRODUCT STRUCTURE
    • PTP1B INHIBITORS
    • CELL-CYCLE
    • BIOLOGICAL-ACTIVITIES
    • LIBRARY DEVELOPMENT

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