Areas covered in the review: We describe the role of the sympathetic nervous system, beta-blockers and specifically nebivolol in chronic heart failure.
What the reader will gain: Nebivolol is a third-generation beta-blocker, with high beta(1)/beta(2) selectivity. Moreover, it has important vasodilating properties, by stimulating the production of nitric oxide. Smaller studies have already shown beneficial effects of nebivolol treatment on surrogate end points in heart failure patients. The recently published SENIORS (Phase III) study in an elderly heart failure population demonstrated a decreased number of clinical events in patients treated with nebivolol. Importantly, this effect was observed in patients with both impaired and preserved left ventricular systolic function.
Take home message: Specific beta-blockers may have distinct effects in various subgroups of heart failure patients. So far, nebivolol is the only beta-blocker to have been shown effective in elderly heart failure patients, regardless of their left ventricular ejection fraction.
|Number of pages||10|
|Journal||EXPERT OPINION ON PHARMACOTHERAPY|
|Publication status||Published - Apr-2010|
- chronic heart failure
- nitric oxide
- sympathetic nervous system
- 3RD-GENERATION BETA-BLOCKER
- IDIOPATHIC DILATED CARDIOMYOPATHY
- VENTRICULAR EJECTION FRACTION
- NITRIC-OXIDE RELEASE