Necroptosis in Cholangiocarcinoma

Samantha Sarcognato, Iris E. M. de Jong, Luca Fabris, Massimiliano Cadamuro, Maria Guido*

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

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    Abstract

    Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and is regulated by receptor-interacting protein kinases 1 and 3 and mixed-lineage kinase domain-like, which form a regulatory complex called the necrosome. Accumulating evidence suggests that necroptosis plays a complex role in cancer, which is likely context-dependent and can vary among different types of neoplasms. Necroptosis serves as an alternative mode of programmed cell death overcoming apoptosis and, as a pro-inflammatory death type, it may inhibit tumor progression by releasing damage-associated molecular patterns to elicit robust cross-priming of anti-tumor CD8+ T cells. The development of therapeutic strategies triggering necroptosis shows great potential for anti-cancer therapy. In this review, we summarize the current knowledge on necroptosis and its role in liver biliary neoplasms, underlying the potential of targeting necroptosis components for cancer treatment.

    Original languageEnglish
    Article number982
    Number of pages18
    JournalCells
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - Apr-2020

    Keywords

    • necroptosis
    • cholangiocarcinoma
    • cell death
    • regulated cell death
    • PROTEIN-KINASE 3
    • DOMAIN-LIKE PROTEIN
    • CELL-DEATH RECOMMENDATIONS
    • CANCER DRUG-RESISTANCE
    • PROGRAMMED NECROSIS
    • NOMENCLATURE COMMITTEE
    • MOLECULAR-MECHANISMS
    • HEPATIC ISCHEMIA
    • LIVER-INJURY
    • EXPRESSION

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