Neural basis of self-initiative in relation to apathy in a student sample

Claire Kos*, Nicky G. Klaasen, Jan-Bernard C. Marsman, Esther M. Opmeer, Henderikus Knegtering, Andre Aleman, Marie-Jose van Tol

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
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Abstract

Human behaviour can be externally driven, e.g. catching a falling glass, or self-initiated and goaldirected, e.g. drinking a cup of coffee when one deems it is time for a break. Apathy refers to a reduction of self-initiated goal-directed or motivated behaviour, frequently present in neurological and psychiatric disorders. The amount of undertaken goal-directed behaviour varies considerably in clinical as well as healthy populations. In the present study, we investigated behavioural and neural correlates of self-initiated action in a student sample (N=39) with minimal to high levels of apathy. We replicated activation of fronto-parieto-striatal regions during self-initiation. The neural correlates of self-initiated action did not explain varying levels of apathy in our sample, neither when mass-univariate analysis was used, nor when multivariate patterns of brain activation were considered. Other hypotheses, e.g. regarding a putative role of deficits in reward anticipation, effort expenditure or executive difficulties, deserve investigation in future studies.

Original languageEnglish
Article number3264
Number of pages10
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 12-Jun-2017

Keywords

  • SUBCLINICAL NEGATIVE SYMPTOMS
  • ORBITOFRONTAL CORTEX
  • PARKINSONS-DISEASE
  • PREFRONTAL CORTEX
  • BASAL GANGLIA
  • SCHIZOPHRENIA
  • REWARD
  • SCALE
  • DEPRESSION
  • EXPERIENCE

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