Neurological soft signs discriminating mood disorders from first episode schizophrenia

MPM Boks*, PF Liddle, JGM Burgerhof, R Knegtering, RJ Bosch

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

68 Citations (Scopus)

Abstract

Objective: To investigate the specificity of neurological soft signs (NSS) for first episode schizophrenia compared with mood disorders.

Method: We assessed NSS in a sample of 60 healthy controls, 191 first episode psychosis patients and 81 mood disorder patients. We used a principle component analysis to identify dimensions of NSS. We subsequently investigated the specificity of these dimensions for schizophrenia and their relationships with medication and symptom scores.

Results: We identified five dimensions; coordination disorders, movement disorders, increased reflexes, dyskinesia and catatonia. These dimensions were related to neural circuits associated with schizophrenia and mood disorders and included the fronto-striatal-thalamic and the fronto-cerebellar pathway. The movement disorder dimension, which was suggestive for the involvement of the fronto-striatal-thalamic pathway, was specific for first episode schizophrenia independent from medication.

Conclusion: NSS are the result of circuitry dysfunctions rather than overall dysfunction and a particular set of NSS shows specificity for schizophrenia.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalActa Psychiatrica Scandinavica
Volume110
Issue number1
Publication statusPublished - Jul-2004

Keywords

  • schizophrenia
  • mood disorders
  • neurologic signs
  • antipsychotic agents
  • psychomotor performance
  • movement disorders
  • cerebellum
  • eye movement
  • COGNITIVE DYSMETRIA
  • TARDIVE-DYSKINESIA
  • NEGATIVE SYMPTOMS
  • EYE-MOVEMENTS
  • DYSFUNCTION
  • CEREBELLUM
  • ABNORMALITIES
  • DEPRESSION
  • CATATONIA
  • SCALE

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