Never tear us a-PARP: Dealing with DNA lesions during mitosis

Pepijn M Schoonen; Marcel A T M van Vugt

doi:10.1080/23723556.2017.1382670

Never tear us a-PARP: Dealing with DNA lesions during mitosis

Pepijn M Schoonen, Marcel A T M van Vugt

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Abstract

Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.

Original language	English
Article number	e1382670
Number of pages	4
Journal	Molecular & Cellular Oncology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2017.1382670
Publication status	Published - 2018

Keywords

Journal Article
checkpoint
olaparib
Mitosis
PARP
BRCA1/2

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10.1080/23723556.2017.1382670Licence: CC BY-NC-ND

Never tear us a PARP Dealing with DNA lesions during mitosisFinal publisher's version, 1.85 MBLicence: CC BY-NC-ND

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title = "Never tear us a-PARP: Dealing with DNA lesions during mitosis",

abstract = "Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.",

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AB - Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.

KW - Journal Article

KW - checkpoint

KW - olaparib

KW - Mitosis

KW - PARP

KW - BRCA1/2

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DO - 10.1080/23723556.2017.1382670

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JO - Molecular & Cellular Oncology

JF - Molecular & Cellular Oncology

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Never tear us a-PARP: Dealing with DNA lesions during mitosis

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