Never tear us a-PARP: Dealing with DNA lesions during mitosis

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Abstract

Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.

Original languageEnglish
Article numbere1382670
Number of pages4
JournalMolecular & Cellular Oncology
Volume5
Issue number1
DOIs
Publication statusPublished - 2018

Keywords

  • Journal Article
  • checkpoint
  • olaparib
  • Mitosis
  • PARP
  • BRCA1/2

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