New bronchoscopic treatment modalities for patients with chronic bronchitis

Jorine E Hartman*, Justin L Garner, Pallav L Shah, Dirk-Jan Slebos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Chronic bronchitis is a chronic, progressive disease that is difficult to treat. Despite much effort, patients remain highly symptomatic. Currently, a number of innovative bronchoscopic treatments for this disease are under investigation. Liquid nitrogen metered cryospray, bronchial rheoplasty and balloon desobstruction all aim to destroy the hyperplastic goblet cells and excess submucous glands using different strategies. These therapies are in an early phase of clinical research and larger randomised controlled trials are needed to confirm the pilot data available and to evaluate the treatment durability. The fourth technique, targeted lung denervation (TLD), aims to decrease the release of acetylcholine, which regulates smooth muscle tone and mucus production by ablating the parasympathetic nerves running alongside the main bronchi. Evaluation of this treatment is at a more advanced stage and promising effects on exacerbation frequency have been shown. However, confirmation of the benefit in improvement in chronic bronchitis symptoms is still needed.

Original languageEnglish
Article number200281
Number of pages11
JournalEuropean Respiratory Review
Volume30
Issue number159
DOIs
Publication statusPublished - 31-Mar-2021

Keywords

  • LUNG-VOLUME REDUCTION
  • SEVERE EMPHYSEMA
  • ENDOBRONCHIAL VALVES
  • SPRAY CRYOTHERAPY
  • SPUTUM PRODUCTION
  • DENERVATION
  • COPD
  • MULTICENTER
  • THERAPY
  • TRIAL

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