New method for the preparation of solid-phase bound isocyanocarboxylic acids and Ugi reactions therewith

Bernd Henkel*, Michael Sax, Alexander Dömling

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

A novel method of synthesizing solid-phase bound isocyanocarboxylic acids is reported. The potassium salts of four different isocyanocarboxylic acids are coupled onto a brominated resin in DMF in good yields. 32 Ugi reactions were performed using these resins and 24 products were obtained in good to viable purities. © 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)7015-7018
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number37
DOIs
Publication statusPublished - 8-Sep-2003

Keywords

  • carboxylic acid derivative
  • isocyanic acid derivative
  • potassium salt
  • resin
  • article
  • bromination
  • chemical reaction
  • solid
  • synthesis

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